Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology
Beyond the Powerhouse: Integrating Mitonuclear Evolution, Physiology, and Theory in Comparative Biology
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超越动力源：在比较生物学中整合线粒体核进化、生理学和理论
DOI：
10.1093/icb/icz132
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发表时间：
2019
影响因子：
2.6
通讯作者：
Montooth, Kristi L.
中科院分区：
文献类型：
--
作者：
Havird, Justin C.;Weaver, Ryan J.;Milani, Liliana;Ghiselli, Fabrizio;Greenway, Ryan;Ramsey, Adam J.;Jimenez, Ana G.;Dowling, Damian K.;Hood, Wendy R.;Montooth, Kristi L.
真核生物是一个古老的共生的结果，因此，真核细胞基本上拥有两个基因组。因此，核基因组和线粒体基因组编码的基因产物必须以亲密和精确的方式相互作用，以实现真核生物的有氧呼吸。真核生物的这种基因组结构被认为需要核基因组和线粒体基因组之间的永久共同进化来维持共同适应，但两个基因组的存在也为细胞内冲突创造了机会。在构成本研讨会卷的论文集合中，科学家们在跨越巨大生物尺度的不同生物系统中工作，在有丝核相互作用的基础上解决了综合比较生物学的新兴主题。
Eukaryotes are the outcome of an ancient symbiosis and as such, eukaryotic cells fundamentally possess two genomes. As a consequence, gene products encoded by both nuclear and mitochondrial genomes must interact in an intimate and precise fashion to enable aerobic respiration in eukaryotes. This genomic architecture of eukaryotes is proposed to necessitate perpetual coevolution between the nuclear and mitochondrial genomes to maintain coadaptation, but the presence of two genomes also creates the opportunity for intracellular conflict. In the collection of papers that constitute this symposium volume, scientists working in diverse organismal systems spanning vast biological scales address emerging topics in integrative, comparative biology in light of mitonuclear interactions.