Changes of perilymphatic glutamate and cochlear blood flow following ischemia.
Changes of perilymphatic glutamate and cochlear blood flow following ischemia.
复制标题
缺血后外淋巴谷氨酸和耳蜗血流的变化。
DOI：
10.1080/00016489850182116
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
S. Usami
中科院分区：
文献类型：
--
作者：
A. Haruta;K. Matsuda;T. Tono;S. Komune;A. Matsubara;S. Usami
在豚鼠耳蜗缺血模型上，同时测定耳蜗血流量和外淋巴谷氨酸的动态变化。用微透析技术将探针插入鼓阶的基转处，测定谷氨酸。用激光多普勒探头在耳蜗第二回外侧壁上监测耳蜗血流。在电灼小脑前下动脉和供应内耳道的其他血管之前和之后测量这两个参数。在四只动物中，谷氨酸随着耳蜗血流量的下降而增加，然后随着血流量的恢复而减少。在7只血流量持续减少的动物中未观察到谷氨酸正常化。本研究结果表明耳蜗谷氨酸调节系统依赖于耳蜗血流量。
Dynamic changes of perilymphatic glutamate and cochlear blood flow were measured simultaneously in the guinea pig following cochlear ischemia. Glutamate was measured by the microdialysis technique with a probe inserted into the scala tympani at the basal turn. Cochlear blood flow was monitored with a laser-Doppler probe on the lateral wall of the second cochlear turn. Both parameters were measured before and after electrocauterization of the anterior inferior cerebellar artery and other vessels supplying the internal auditory canal. In four animals, glutamate increased with a decline of cochlear blood flow and then decreased with recovery of blood flow. No normalization of glutamate was observed in seven animals with a persistent decrease of blood flow. The results of this study indicate that the glutamate regulating system in the cochlea is dependent on cochlear blood flow.