One-pot synthesis of chiral bicyclo[3.3.0]octatrienes using diphenylprolinol silyl ether-mediated ene-type reaction
One-pot synthesis of chiral bicyclo[3.3.0]octatrienes using diphenylprolinol silyl ether-mediated ene-type reaction
复制标题
DOI：
10.1016/j.tet.2010.03.010
复制
发表时间：
2010-06-26
期刊：
影响因子：
2.1
通讯作者：
Hayashi, Yujiro
中科院分区：
文献类型：
--
作者：
Gotoh, Hiroaki;Ogino, Hiroshi;Hayashi, Yujiro
以α，β-不饱和醛和环戊二烯为起始原料，通过二苯基脯氨醇硅醚介导的烯型反应、环戊二烯与醛的分子内加成反应和脱水反应，一锅法合成了具有良好对映选择性的手性双环[3.3.0]辛三烯. (C)2010爱思唯尔有限公司版权所有。
Chiral bicyclo[3.3.0]octatrienes with excellent enantioselectivity were synthesized from the simple starting materials of alpha,beta-unsaturated aldehyde and cyclopentadiene via one-pot operation, which consisted of a diphenylprolinol silyl ether-mediated ene-type reaction, intramolecular addition reaction of cyclopentadiene moiety with aldehyde and dehydration reaction. (C) 2010 Elsevier Ltd. All rights reserved.