Renal effects of nonsteroidal anti-inflammatory agents.
Renal effects of nonsteroidal anti-inflammatory agents.
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非甾体抗炎药的肾脏作用。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
M. Lifschitz
中科院分区：
文献类型：
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作者：
M. Lifschitz
总之，目前有多种非甾体抗炎药可供临床使用，有时，特别是在患有各种疾病状态的人类中，这些药物有时会导致肾功能相对快速下降，特别是肾小球滤过率。尽管可以预测哪些类别的患者可能更容易受到这种不良事件的影响，但即使在这些患者群体中，这种现象的发生率也相对不常见，并且并不排除使用这些药物，而是建议医生在给药期间保持警惕。尽管考虑这些影响部分是由于内源性前列腺素减少所致的可能性很有吸引力，但这个问题仍然有待积极研究。
In conclusion, there are a large variety of nonsteroidal anti-inflammatory drugs presently available for clinical use, which on occasion, particularly in human beings with a variety of disease states, can lead to relatively rapid decreases in renal function, particularly glomerular filtration rate. Although it is possible to predict which classes of patients may be more susceptible to this untoward event, even in these groups of patients the incidence of this phenomenon is relatively uncommon and does not preclude the use of these drugs, but rather it suggests that the physician be wary during their administration. Although it is attractive to consider the possibility that these effects are, in part, due to a decrease in endogenous prostaglandins, this issue is still open to active investigation.