The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population.
The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population.
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脑白质变化对中风人群认知和身体活动心血管反应的影响。
DOI：
10.1111/j.1469-8986.2012.01467.x
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Porges,SW
中科院分区：
文献类型：
--
作者：
Williamson,JB;Lewis,GF;Nyenhuis,DL;Stebbins,GT;Murphy,C;Handelman,M;Harden,E;Heilman,KM;Gorelick,PB;Porges,SW
自主神经系统（ANS）的控制可能会被脑血管疾病破坏。我们调查了23名在5年内中风的参与者的白色物质完整性和ANS调节的改变之间的关系。这些参与者接受了弥散张量成像，并计算了每个半球和叶的各向异性分数值（DTI‐FA）。在记录心电图的同时进行认知和体力消耗任务。呼吸性窦性心律失常（RSA）在使用左下半球DTI‐FA的语言流畅性任务期间减少更多。此外，身体应激导致RSA降低，额叶DTI-FA降低，颞叶DTI-FA升高，p<0.05（可能是对中枢自主神经网络的释放效应）。ANS调节的下降可能具有改变行为的功能后果，以及潜在地增加进一步血管疾病的风险。
Autonomic nervous system (ANS) control may be disrupted by cerebrovascular disease. We investigated the relationship between alterations in white matter integrity and regulation of the ANS in 23 participants who sustained a stroke within 5 years. These participants underwent diffusion tensor imaging, and fractional anisotropy values were calculated (DTI‐FA) for each hemisphere and lobe. Cognitive and physical exertion tasks were performed while recording an electrocardiogram. Respiratory sinus arrhythmia (RSA) decreased more during a verbal fluency task with lower left hemisphere DTI‐FA. Further, the physical stressor yielded decreases in RSA with lower frontal DTI‐FA and higher temporal lobe DTI‐FA,p< .05 (perhaps a release effect on the central autonomic network). Decrements in ANS regulation may have functional consequences that alter behavior, as well as potentially increasing the risk for further vascular disease.