Bone augmentation osteogenesis using hydroacyapatite and β-tricalcium phosphate blocks
Bone augmentation osteogenesis using hydroacyapatite and β-tricalcium phosphate blocks
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DOI：
10.1016/s0278-2391(03)00317-3
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发表时间：
2003-09-01
影响因子：
1.9
通讯作者：
Kohgo, T
中科院分区：
文献类型：
--
作者：
Fujita, R;Yokoyama, A;Kohgo, T
目的：在这项研究中，我们研究了羟基磷灰石（HA）和β-磷酸三钙（β-TCP）植入大鼠顶骨的成骨和吸收的差异。材料和方法：HA和β-TCP被用于大孔和微孔块。将其植入大鼠顶骨和颅骨骨膜之间。术后1、2、4、8、24周对植入材料周围的成骨情况进行组织病理学和组织形态计量学研究。结果：2周时，两种材料周围均可见顶骨成骨，新骨直接附着于两种材料表面。随着时间的推移，新骨生长到两种材料上部区域的孔隙中。β-TCP块具有典型的嗜碱性网状结构，其中在靠近新骨处观察到材料溶解。HA块在24周内保持稳定，而部分β-TCP块在24周时发生断裂和吸收。组织形态学上，HA周围的新骨体积大于β-TCP周围。结论：本模型中的HA块具有良好的稳定性和成骨能力，适合作为高嵌体移植材料，而β-TCP不稳定。因此，当β-TCP块用于表面移植物时，由于吸收和断裂，应考虑受体部位的机械应力。(C)2003年美国口腔颌面外科医师协会。
Purpose: In this study, we investigated the differences in osteogenesis and resorption between hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) implanted on the parietal bone of rats.Materials and Methods: HA and beta-TCP were used in blocks with macropores and micropores. They were implanted between the parietal bone and the cranial periosteum in rats. Osteogenesis around the implanted materials was investigated histopathologically and histomorphometrically at 1, 2, 4, 8, and 24 weeks after surgery.Results: At 2 weeks, osteogenesis from the parietal bone was observed around both materials, and new bone had attached directly to the surfaces of both materials. New bone grew into the pores of the upper regions of both materials with time. The beta-TCP block had a characteristic basophilic reticular structure in which the dissolution of the materials was observed close to the new bone. The HA blocks were stable for 24 weeks, whereas parts of the beta-TCP blocks were fractured and resorbed at 24 weeks. Histomorphometrically, the volume of new bone around HA was larger than that around beta-TCP. There was no remarkable change in the amount of remaining HA, but that of beta-TCP was decreased.Conclusion: HA blocks in this model are suitable for onlay grafts because of its stability and osteogenesis,beta-TCP is not stable. Therefore, when beta-TCP blocks are used for onlay grafts, the mechanical stress on the recipient site should be taken into consideration because of resorption and fracture. (C) 2003 American Association of Oral and Maxillofacial Surgeons.