Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula
Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula
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DOI：
10.1021/np000456u
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发表时间：
2001-03-01
影响因子：
5.1
通讯作者：
Paul, VJ
中科院分区：
文献类型：
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作者：
Luesch, H;Pangilinan, R;Paul, VJ
从关岛Piti Bomb Holes收集的海洋蓝细菌Lyngbya majuscula种群中分离出两种新的环缩肽。它们似乎是这一特定的关岛收藏所特有的，并被命名为pitipeptolides A（1）和B（2）。它们的结构已通过光谱技术和降解产物的表征进行了阐明。独特的特征包括在1中存在2，2-二甲基-3-羟基-7-辛炔酸残基和在2中存在2，2-二甲基-3-羟基-7-辛烯酸残基，先前显示为蓝藻代谢物的生物合成特征。Pitipeptolides A（1）和B（2）对LoVo癌细胞表现出弱的细胞毒性，但具有中等的抗分枝杆菌活性并刺激弹性蛋白酶活性。
Two new cyclodepsipeptides have been isolated from a population of the marine cyanobacterium Lyngbya majuscula collected at Piti Bomb Holes, Guam. They appear to be unique to this particular Guamanian collection and have been named pitipeptolides A (1) and B (2). Their structures have been elucidated by spectroscopic techniques and by characterization of degradation products. Distinctive features include the presence of a 2,2-dimethyl-3 -hydroxy-7-octynoic acid residue in 1 and a 2,2-dimethyl-3-hydroxy- 7-octenoic acid residue in 2, previously shown to be biosynthetic signatures of cyanobacterial metabolites. Pitipeptolides A(1) and B (2) exhibit weak cytotoxicity against LoVo cancer cells, but possess moderate antimycobacterial activity and stimulate elastase activity.