Social interaction with a cagemate in pain facilitates subsequent spinal nociception via activation of the medial prefrontal cortex in rats
Social interaction with a cagemate in pain facilitates subsequent spinal nociception via activation of the medial prefrontal cortex in rats
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与疼痛中的笼友进行社交互动，通过激活大鼠内侧前额叶皮层，促进随后的脊髓伤害感受
DOI：
10.1016/j.pain.2014.03.019
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发表时间：
2014-07-01
期刊：
影响因子：
7.4
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
Li, Zhen;Lu, Yun-Fei;Chen, Jun
对他人疼痛体验的共鸣可以导致与疼痛相关的大脑区域的激活，甚至可以在人类观察者中诱导对疼痛的异常反应。最近的证据表明，这种高水平的情感和认知过程也存在于低等动物中；然而，这种现象背后的机制仍然不清楚。在本研究中，我们发现，在与一只皮下注射蜂毒(BV)的大鼠进行社会互动后，只有笼状观察者(CO)而不是非笼状观察者(NCO)在注射BV后表现出双侧机械超敏反应和增强的爪缩反射。此外，注射BV后1h，CO大鼠脊髓背角c-Fos免疫反应标记的神经元活性也明显高于对照组。CO大鼠与NCO大鼠和隔离对照组大鼠相比，在与示痛大鼠进行社会互动后，血清皮质酮浓度没有发生变化，因此可以排除与应激相关的反应。焦虑也可以被排除，因为在旷场测试中，CO和NCO大鼠都可以看到类似焦虑的行为。最后，双侧损毁内侧前额叶皮质消除了BV诱导的CO大鼠爪缩反射的增强，但双侧杏仁核或内嗅觉皮质的损毁都失败了。总之，我们提供了另一条证据，证明了大鼠存在熟悉依赖的疼痛共情，并证明了内侧前额叶皮质在处理与共情相关的脊髓伤害性增强过程中发挥着关键作用。(C)2014年国际疼痛研究协会。爱思唯尔出版，版权所有。
Empathy for the pain experience of others can lead to the activation of pain-related brain areas and can even induce aberrant responses to pain in human observers. Recent evidence shows this high-level emotional and cognitive process also exists in lower animals; however, the mechanisms underlying this phenomenon remain unknown. In the present study we found that, after social interaction with a rat that had received subcutaneous injection of bee venom (BV), only the cagemate observer (CO) but not the noncagemate observer (NCO) showed bilateral mechanical hypersensitivity and an enhanced paw flinch reflex following BV injection. Moreover, neuronal activities labeled by c-Fos immunoreactivity in the spinal dorsal horn of CO rats were also significantly increased relative to the control 1 hour after BV injection. A stress-related response can be excluded because serum corticosterone concentration following social interaction with demonstrator rats in pain was not changed in CO rats relative to NCO and isolated control rats. Anxiety can also be excluded because anxiety-like behaviors could be seen in both the CO and NCO rats tested in the open-field test. Finally, bilateral lesions of the medial prefrontal cortex eliminated the enhancement of the BV-induced paw flinch reflex in CO rats, but bilateral lesions of either the amygdala or the entorhinal cortex failed. Together, we have provided another line of evidence for the existence of familiarity-dependent empathy for pain in rats and have demonstrated that the medial prefrontal cortex plays a critical role in processing the empathy-related enhancement of spinal nociception. (C) 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.