A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production
A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production
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DOI：
10.1039/c1cc10589b
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Yoon, Juyoung
中科院分区：
文献类型：
--
作者：
Chen, Xiaoqiang;Lee, Kyung-Ah;Yoon, Juyoung
开发了一种特异性和灵敏的基于荧光的方法，用于对微生物诱导的次氯酸（HOCl）产生进行成像。此外，我们证明了在活体动物的黏膜中双氧化酶（DUOX）介导的次氯酸产生，这为黏膜固有免疫提供了新的见解。
A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.