Factors associated with enrollment of African Americans into a clinical trial: Results from the African American study of kidney disease and hypertension
Factors associated with enrollment of African Americans into a clinical trial: Results from the African American study of kidney disease and hypertension
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DOI：
10.1016/j.cct.2008.06.001
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发表时间：
2008-11-01
影响因子：
2.2
通讯作者：
Jamerson, Kenneth A.
中科院分区：
文献类型：
--
作者：
Gadegbeku, Crystal A.;Stillman, Phyllis Kreger;Jamerson, Kenneth A.
招募不同人群参与临床试验仍然具有挑战性，但需要充分了解疾病过程并使公众受益。更多地了解少数民族和种族人群中与决定参与临床研究相关的关键因素可能有助于招募并提高研究结果的普遍性。因此，在非裔美国人肾病和高血压研究（AASK）试验的招募阶段，我们进行了电话调查。使用验证的问题，探索潜在的促进者和研究参与的障碍之间的合格的候选人居住在美国的七个地点。调查的回答包括一系列的特点和参与者和非参与者之间的看法，并进行了比较，使用双变量和逐步logistic回归analysis.141受访者在140（70名试验参与者和71名非参与者）完成了调查。试验参与者和非参与者在多个人口统计学特征方面相似，并且在歧视和医生不信任方面有着相似的观点。和研究诚信。关键的群体差异与他们对参与研究的影响的看法有关。参与者将入学与个人和社会健康益处相关联。而非参与者则受到健康风险的影响。在逐步线性回归分析中，参与的最强有力的积极预测因素是承认健康状况在入组决策中的重要性（OR = 4.54，p = 0.006），就业（OR = 3.12，p = 0.05）和医疗保健满意度（OR = 2.12，p < 0.01）。基于种族的不信任并没有成为一个负面的预测因素，受试者的决定不受研究人员的种族。而不是心理社会的看法，对非裔美国人的研究参与有主导影响。(C)2008年爱思唯尔公司All rights reserved.
Recruitment of diverse populations into clinical trials remains challenging but is needed to fully understand disease processes and benefit the general public. Greater knowledge of key factors among ethnic and racial minority populations associated with the decision to participate in clinical research studies may facilitate recruitment and enhance the generalizibility of study results. Therefore, during the recruitment phase of the African American Study of Kidney Disease and Hypertension (AASK) trial, we conducted a telephone survey. using validated questions, to explore potential facilitators and barriers of research participation among eligible candidates residing in seven U.S. locations. Survey responses included a range of characteristics and perceptions among participants and non-participants and were compared using bivariate and step-wise logistic regression analyses.One-hundred forty-one respondents in the one-hundred forty (70 trial participants and 71 nonparticipants) completed the Survey. Trial participants and non-participants were similar in multiple demographic characteristics and shared similar views on discrimination, physician mistrust. and research integrity. Key group differences were related to their perceptions of the impact of their research participation. Participants associated enrollment with personal and societal health benefits. while non-participants were influenced by the health risks. In a stepwise linear regression analysis, the most powerful significant positive predictors of participation were acknowledgement of health status as important in the enrollment decision (OR = 4.54, p = 0.006), employment (OR = 3.12, p = 0.05) and healthcare satisfaction (OR = 2.12, p < 0.01). Racially-based mistrust did not emerge as a negative predictor and subjects' decisions were not influenced by the race of the research staff.In conclusion, these results suggest that health-related factors. and not psychosocial perceptions, have predominant influence on research participation among African Americans. (C) 2008 Elsevier Inc. All rights reserved.