Laser-induced photo-thermal magnetic imaging.
Laser-induced photo-thermal magnetic imaging.
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DOI：
10.1063/1.4742158
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发表时间：
2012-08
影响因子：
4
通讯作者：
D. Thayer;Yuting Lin;A. Luk;G. Gulsen
中科院分区：
文献类型：
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作者：
D. Thayer;Yuting Lin;A. Luk;G. Gulsen
由于生物组织的强散射特性，超过扩散极限的光学成像空间分辨率较低。在这封信中，我们提出了一种成像技术，激光诱导光热磁成像（PMI），它使用激光照明来诱导介质中的温度升高，并用磁共振成像来映射空间变化的温度，这与吸收的能量成正比。这项技术可以提供高分辨率的光学吸收图像，可以潜在地用于小动物以及乳腺癌和淋巴结成像。首先，我们描述了PMI的理论，包括光在组织中的传播和热传递的建模。我们还提供了与理论模型预测相对应的实验数据，结果非常吻合。
Due to the strong scattering nature of biological tissue, optical imaging beyond the diffusion limit suffers from low spatial resolution. In this letter, we present an imaging technique, laser-induced photo-thermal magnetic imaging (PMI), which uses laser illumination to induce temperature increase in a medium and magnetic resonance imaging to map the spatially varying temperature, which is proportional to absorbed energy. This technique can provide high-resolution images of optical absorption and can potentially be used for small animal as well as breast cancer and lymph node imaging. First, we describe the theory of PMI, including the modeling of light propagation and heat transfer in tissue. We also present experimental data with corresponding predictions from theoretical models, which show excellent agreement.