Treatment of primary intracranial germ cell tumors: Single-center experience with 42 clinically diagnosed cases
Treatment of primary intracranial germ cell tumors: Single-center experience with 42 clinically diagnosed cases
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原发性颅内生殖细胞肿瘤的治疗：单中心42例临床诊断经验
DOI：
10.18632/oncotarget.10218
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发表时间：
2016-09-13
期刊：
影响因子：
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通讯作者：
Chen, Zhong-Ping
中科院分区：
文献类型：
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作者：
Yang, Qun-Ying;Guo, Cheng-Cheng;Chen, Zhong-Ping
背景与目的原发性颅内生殖细胞肿瘤是一类异质性肿瘤。手术可以迅速解除肿瘤压迫，并提供组织学诊断。一些无法进行病理诊断的患者很难得到治疗。我们的目的是分析临床诊断为GCTS的患者。方法对临床诊断为原发性颅内GCTS的患者进行研究。结果2002~2015年间，42例临床诊断为颅内GCTS的患者接受了化疗和/或放射治疗。根据首次抗肿瘤治疗分为诊断化疗组(25例)、诊断放疗组(5例)和伽玛刀放疗组(12例)。5年生存率分别为85.8%、75.0%和63.6%。两组间差异无统计学意义(p值=0.44)。根据肿瘤标志物水平将患者分为分泌型肿瘤组(30例)和非分泌型肿瘤组(12例)。5年生存率分别为80.7%和68.6%。不良反应主要为III~IV度骨髓抑制，发生率为35.2%，II~III度恶心呕吐发生率为45.8%。结论手术切除肿瘤或活检是确定肿瘤病理性质的最准确方法。但对于一些无法病理诊断的患者，他们可以接受化疗结合放射治疗等综合治疗，其中一些人仍然可以有良好的反应。
Background and Objective Primary intracranial germ cell tumors (GCTs) are a class of heterogeneous tumors. Surgery can quickly relieve tumor compression and provide histological diagnosis. It is very difficult to treat some patients who are unable to be pathologically diagnosed. We aimed to analyze clinically diagnosed GCTs patients. Methods Patients clinically diagnosed as primary intracranial GCTs were included in this study. Results From 2002 to 2015, 42 patients clinically diagnosed with primary intracranial GCTs received chemotherapy and/or radiotherapy. Patients were assigned to diagnostic chemotherapy group (25 cases), diagnostic radiotherapy group (5 cases) and gamma knife radiosurgery group (12 cases) based on their initial anti-tumor therapy. The 5-year survival rates were 85.8%, 75.0% and 63.6%, respectively. There were no statistically significant difference (p value = 0.44). Patients were assigned to the group (30 cases) with secretory tumors and the group (12 cases) with non-secretory tumors based on their levels of tumor makers. The 5- year survival rates were 80.7% and 68.6%, respectively. There were no statistically significant difference (p value = 0.49).The major adverse reactions were grade III - IV bone marrow suppression with an incidence of 35.2% and grade II- III nausea/vomiting with an incidence of 45.8%. Conclusion Surgical removal of tumor or biopsy is recognized as the most accurate method to determine the pathological property of tumor. But for some patients who can not be pathologically diagnosed, they can receive comprehensive treatments such as chemotherapy combined with radiotherapy, and some of them can still have good responses.