EMBRYONIC EXPRESSION AND FUNCTION OF THE DROSOPHILA HELIX-LOOP-HELIX GENE, EXTRAMACROCHAETAE
EMBRYONIC EXPRESSION AND FUNCTION OF THE DROSOPHILA HELIX-LOOP-HELIX GENE, EXTRAMACROCHAETAE
复制标题
DOI：
10.1016/0925-4773(94)90096-5
复制
发表时间：
1994-07-01
影响因子：
2.6
通讯作者：
ELLIS, HM
中科院分区：
文献类型：
--
作者：
ELLIS, HM
外巨毛纲（emc）编码HLH蛋白，该HLH蛋白凭借其与无毛鳞片复合体（AS-C）和/或无子体（da）基因的bHLH产物形成无活性异二聚体的能力而作为感觉器官前体形成的调节剂发挥作用。虽然合子emc功能是胚胎生存所必需的，但它在胚胎发生中的作用还不清楚。我们在这里描述的分布emc转录在胚胎发育。我们还表明，电磁兼容性的成绩单是母亲的贡献。最后，我们证明，EMC功能是正常的中肠和马氏管发育所必需的。这些结果表明，负调控emc可能是一个共同的特点，发育过程涉及da，AS-C和可能的其他螺旋-环-螺旋蛋白。
extramacrochaetae (emc) encodes a HLH protein that functions as a regulator of sensory organ precursor formation by virtue of its ability to form inactive heterodimers with the bHLH products of the achaete-scute complex (AS-C) and/or daughterless (da) genes. Although zygotic emc function is required for embryonic viability, its role in embryogenesis is not well understood. We describe here the distribution of emc transcripts during embryonic development. We also show that emc transcript is maternally contributed. Finally, we demonstrate that emc function is required for normal midgut and Malpighian tubule development. These results suggest that negative regulation by emc may be a common feature of developmental processes involving da, the AS-C and possibly other helix-loop-helix proteins.