Premature menopause in survivors of childhood cancer: A report from the childhood cancer survivor study
Premature menopause in survivors of childhood cancer: A report from the childhood cancer survivor study
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DOI：
10.1093/jnci/djj243
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发表时间：
2006-07-05
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影响因子：
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通讯作者：
Robison, Leslie L.
中科院分区：
文献类型：
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作者：
Sklar, Charles A.;Mertens, Ann C.;Robison, Leslie L.
背景在完成癌症治疗后保留卵巢功能的儿童癌症幸存者发生过早绝经的风险增加，过早绝经定义为40岁之前月经停止。然而，有关过早绝经的风险和频率的已发表数据有限。研究方法：我们评估了2819名年龄超过18岁的儿童癌症幸存者中过早绝经的发生率和危险因素，这些幸存者是多中心儿童癌症幸存者研究（CCSS）的参与者。对照组为CCSS参与者的1065名女性兄弟姐妹。构建了一个多元Poisson回归模型来确定非手术性过早绝经的危险因素。所有统计检验均为双侧检验。结果：共有126名儿童癌症幸存者和33名对照兄弟姐妹过早绝经。在这些妇女中，61名幸存者（48%）和31名兄弟姐妹（94%）手术诱导绝经（率比[RR] = 0.8，95%置信区间[CI] = 0.52至1.23）。然而，非手术性过早绝经的累积发生率在幸存者中高于同胞（8%对0.8%; RR = 13.21，95%CI = 3.26至53.51; P
Background. Childhood cancer survivors who retain ovarian function after completing cancer treatment are at increased risk of developing premature menopause, defined as cessation of menses before age 40 years. However, published data pertaining to the risk and frequency of premature menopause are limited. Methods: We assessed the incidence of and risk factors for premature menopause in 2819 survivors of childhood cancer who were older than 18 years and were participants in the multicenter Childhood Cancer Survivor Study (CCSS). The comparison group was 1065 female siblings of participants in the CCSS. A multiple Poisson regression model was constructed to determine risk factors for nonsurgical premature menopause. All statistical tests were two-sided. Results: A total of 126 childhood cancer survivors and 33 control siblings developed premature menopause. Of these women, 61 survivors (48%) and 31 siblings (94%) had surgically induced menopause (rate ratio [RR] = 0.8, 95% confidence interval [CI] = 0.52 to 1.23). However, the cumulative incidence of nonsurgical premature menopause was higher for survivors than for siblings (8% versus 0.8%; RR = 13.21, 95% CI = 3.26 to 53.51; P