Erythromycin induces migrating motor complex in human gastrointestinal tract
Erythromycin induces migrating motor complex in human gastrointestinal tract
复制标题
红霉素诱导人胃肠道迁移运动复合体
DOI：
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发表时间：
1986
影响因子：
3.1
通讯作者：
Z. Itoh
中科院分区：
文献类型：
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作者：
T. Tomomasa;T. Kuroume;H. Arai;K. Wakabayashi;Z. Itoh
15名健康受试者，禁食至少8小时，用输注测压方法进行研究。十二指肠自然III相活动终止20分钟后，静脉注射红霉素或生理盐水15分钟。当输注生理盐水时(N=5)，下一个移行运动复合体在输注后151.2±42.1min开始。而以1.0 mg/kg/小时(N=5)或3.0 mg/kg/小时(N=5)的速度滴注红霉素时，MMC样收缩开始的时间间隔较短，分别为47.8±40.9min(P<；0.005)和23.0±13.0min(P<；0.001)。自然发生的MMC(N-MMC)的持续时间、频率、幅度和迁移速度与红霉素诱发的收缩的持续时间、频率、幅度和迁移速度无显著差异，但胃内III相收缩的持续时间(5.3±2.2分钟)显著长于(3.2±0.9)分钟(P<；0.05)。注射红霉素后，胃动素(IRM)免疫反应性浓度与注射生理盐水后相比无明显升高。结果表明，与胃动素相似，在消化间期给予红霉素1~3 mg/kg/h，作用15min，对人胃肠道MMC的启动有显著影响，但是否与内源性胃动素有关，尚需进一步研究。
Fifteen healthy subjects, fasted at least 8 hr, were studied by means of an infused manometric method. Twenty minutes after termination of the natural phase III activity in the duodenum, erythromycin or normal saline was administered intravenously for 15 min. When normal saline (N=5) was infused, the next migrating motor complex (MMC) was initiated 151.2±42.1 min after the infusion. On the other hand, when erythromycin was infused at a rate of 1.0 mg/kg/hr (N=5) or 3.0 mg/kg/hr (N=5), MMC-like contractions were initiated at shorter intervals, ie, 47.8±40.9 min (P<0.005) or 23.0±13.0 min (P <0.001), respectively. The duration, frequency, amplitude, and migrating velocity of the naturally occurring MMC (N-MMC) were not significantly different from those of the erythromycin-induced contractions except for the duration of the phase III contractions in the stomach; the duration (5.3±2.2 min) of the erythromycin-induced contractions being significantly (P<0.05) longer than that (3.2±0.9 min) of the naturally occurring MMC. The immunoreactive motilin (IRM) concentration did not increase significantly after the infusion of erythromycin, when compared to that after infusion of normal saline. It is concluded that erythromycin at a dose of 1–3 mg/kg/hr for 15 min during the interdigestive state, similar to motilin, has a significant influence upon the initiation of MMC in the human gastrointestinal tract, but further investigations are required to confirm whether endogenous motilin is involved or not.