Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy.
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DOI：
10.1016/s0021-9258(18)48217-8
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发表时间：
1987-05
期刊：
影响因子：
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通讯作者：
W. Burtis;T. Wu;C. Bunch;J. Wysolmerski;K. Insogna;E. C. Weir;A. Broadus;A. F. Stewart
中科院分区：
文献类型：
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作者：
W. Burtis;T. Wu;C. Bunch;J. Wysolmerski;K. Insogna;E. C. Weir;A. Broadus;A. F. Stewart
恶性肿瘤的体液高钙血症是一种常见的副肿瘤综合征，其特征是肿瘤分泌循环骨吸收因子引起的高钙血症。有证据表明，在许多情况下，该因子是一种腺苷酸环化酶刺激蛋白，与甲状旁腺激素 (PTH) 具有相同的特征，但又有所不同。目前的报告描述了从恶性肿瘤相关肿瘤的体液高钙血症中纯化出一种新型的、基本的、高效的 PTH 样腺苷酸环化酶刺激蛋白。该因子在大小、氨基酸组成和比活性方面与之前描述的 PTH 样因子不同。
Humoral hypercalcemia of malignancy is a common paraneoplastic syndrome which is characterized by hypercalcemia resulting from secretion by tumors of a circulating bone-resorbing factor. Evidence suggests that in many instances this factor is an adenylate cyclase-stimulating protein which shares features with, but is distinct from, parathyroid hormone (PTH). The current report describes the purification to homogeneity from a humoral hypercalcemia of malignancy-associated tumor of a novel, basic, highly potent PTH-like adenylate cyclase-stimulating protein. This factor differs from previously described PTH-like factors with respect to size, amino acid composition, and specific activity.