Prevalence of autoimmune inflammatory myopathy in the first nations population of Alberta, Canada
Prevalence of autoimmune inflammatory myopathy in the first nations population of Alberta, Canada
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DOI：
10.1002/acr.21743
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发表时间：
2012-11-01
影响因子：
4.7
通讯作者：
Bernatsky, Sasha
中科院分区：
文献类型：
--
作者：
Barnabe, Cheryl;Joseph, Lawrence;Bernatsky, Sasha
目的 估计加拿大阿尔伯塔省基于人群的自身免疫性炎症性肌病 (AIM) 患病率，特别关注原住民人群中的患病率。方法 使用阿尔伯塔省 (19942007) 的医生账单索赔和住院数据，根据 3 个病例定义来估计患有 AIM（即多发性肌炎或皮肌炎）的概率。采用潜在类别贝叶斯分层回归模型来解释病例确定中计费和住院数据的不完善的敏感性和特异性。在估计原住民和非原住民人口中的患病率时，我们考虑了性别、年龄组和居住地点（城市或农村）等人口因素。结果 AIM 的总体患病率在原住民群体中为每 10 万人 25.0 人（95% 可信区间 [95% CrI] 13.449.0），在原住民群体中为 33.8 人（95% CrI 28.939.6）。非原住民人口。对于这两个群体，女性相对于男性、农村女性相对于城市女性以及年龄 >45 岁的人群中，患病率均有所增加。 结论 与类风湿性关节炎、系统性红斑狼疮和系统性硬化症等其他风湿病不同，我们没有发现艾伯塔省原住民人口中 AIM 患病率相对于非原住民人口有所增加。潜在的限制包括编码错误、原住民成员身份不明以及原住民人口在获得护理方面的公认差异。
Objective To estimate the population-based prevalence of autoimmune inflammatory myopathy (AIM) in Alberta, Canada, with a specific focus on rates in the First Nations population.Methods Physician billing claims and hospitalization data for the province of Alberta (19942007) were used to estimate the probability of having AIM (i.e., polymyositis or dermatomyositis) based on 3 case definitions. A latent class Bayesian hierarchical regression model was employed to account for the imperfect sensitivity and specificity of billing and hospitalization data in case ascertainment. We accounted for demographic factors of sex, age group, and location of residence (urban or rural) in estimating the prevalence rates within the First Nations and nonFirst Nations populations.Results The overall prevalence of AIM was 25.0 per 100,000 persons (95% credible interval [95% CrI] 13.449.0) in the First Nations population and 33.8 (95% CrI 28.939.6) in the nonFirst Nations population. For both groups, prevalence was increased in women relative to men, rural women relative to urban women, and in those age >45 years.Conclusion Unlike other rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis, we did not detect an increased prevalence of AIM in Alberta's First Nations population relative to the nonFirst Nations population. Potential limitations include coding errors, underidentification of First Nations members, and recognized differences in access to care for the First Nations population.