Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission
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DOI：
10.1038/sj.onc.1204192
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发表时间：
2001-03-26
期刊：
影响因子：
8
通讯作者：
Ullrich, A
中科院分区：
文献类型：
--
作者：
Gschwind, A;Zwick, E;Ullrich, A
不同的细胞信号系统之间的通信已经成为一种共同的原则，使细胞能够整合来自其环境的多种信号。表皮生长因子受体(EGFR)的反式激活代表了G蛋白偶联受体(GPCRs)和受体酪氨酸激酶(RTK)之间相互作用的范例，最近发现依赖于锌的金属蛋白酶和跨膜生长因子前体是GPCRs诱导的EGFR反式激活途径中的关键元件，这定义了一个迅速增加的复杂性的细胞通讯网络的新组成部分。进一步阐明EGFR反式激活机制的分子细节将对其与正常生理过程的相关性及其病理生理偏离提供新的理解。
Communication between different cellular signaling systems has emerged as a common principle that enables cells to integrate a multitude of signals from its environment. Transactivation of the epidermal growth factor receptor (EGFR) represents the paradigm for cross-talk between G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs), The recent identification of Zn2+-dependent metalloproteinases and transmembrane growth factor precursors as critical elements in GPCR-induced EGFR transactivation pathways has defined new components of a cellular communication network of rapidly increasing complexity. Further elucidation of the molecular details of the EGFR transactivation mechanism will provide new understanding of its relevance for normal physiological processes and their pathophysiological deviations.