Cross-sectional associations of asthma, hay fever, and other allergies with major depression and low-back pain among adults aged 20-39 years in the United States
Cross-sectional associations of asthma, hay fever, and other allergies with major depression and low-back pain among adults aged 20-39 years in the United States
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DOI：
10.1093/oxfordjournals.aje.a009936
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发表时间：
1999-11-15
影响因子：
5
通讯作者：
Morgenstern, H
中科院分区：
文献类型：
--
作者：
Hurwitz, EL;Morgenstern, H
尽管腰痛和抑郁症是常见的合并症，但其相关机制仍不清楚。促炎细胞因子对下丘脑-垂体-肾上腺 (HPA) 轴的影响导致了这样的假设：过敏反应作为炎症相关的 HPA 轴激活的标志物，会导致对后续应激源的异常反应。使用来自第三次全国健康和营养检查调查（1988-1994）的 6,836 名 20-39 岁美国成年人的数据。受试者回答了有关过去 12 个月内腰痛以及哮喘、花粉热和其他过敏史的问题。重度抑郁症的病史和发病情况是从诊断访谈时间表中获得的。使用逻辑回归模型来估计过敏与抑郁和腰痛之间的关联。有任何过敏史的受试者更有可能报告腰痛（比值比 = 1.51；95% 置信区间：1.16, 1.96），被诊断为重度抑郁症（比值比 = 1.58；95% 置信区间：1.13, 2.21），并且更有可能同时患有重度抑郁症和腰痛（比值比 = 3.03；95% 置信区间：1.13, 2.21）。 95% 置信区间：1.32、6.92）。超敏反应可能会促使 HPA 轴对压力源做出异常反应，从而导致身体和行为后果。
Although low-back pain and depression are common comorbidities, the mechanisms responsible for their association remain unclear. The effects of proinflammatory cytokines on the hypothalamic-pituitary-adrenal (HPA) axis lead to the hypothesis that allergic reactions, as markers for inflammation-associated activation of the HPA axis, result in aberrant responses to subsequent stressors. Data from 6,836 US adults 20-39 years old from the Third National Health and Nutrition Examination Survey (1988-1994) were used. Subjects responded to questions regarding low-back pain in the past 12 months and history of asthma, hay fever, and other allergies. The history and onset of major depression were obtained from the Diagnostic Interview Schedule. Logistic regression modeling was used to estimate the associations between allergies and depression and low-back pain. Subjects with a history of any allergy were more likely to report low-back pain (odds ratio = 1.51; 95% confidence interval: 1.16, 1.96), to be diagnosed with major depression (odds ratio = 1.58; 95% confidence interval: 1.13, 2.21), and much more likely to have both major depression and low-back pain (odds ratio = 3.03; 95% confidence interval: 1.32, 6.92). Hypersensitivity reactions may prime the HPA axis to respond aberrantly to stressors, resulting in physical and behavioral consequences.