Automated DNA Sequencing: Progress and Prospects
Automated DNA Sequencing: Progress and Prospects
复制标题
自动 DNA 测序：进展与前景
DOI：
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复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Davies
中科院分区：
文献类型：
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作者：
W. J. Martin;R. Davies
In the decade since their inception, manual DNA sequencing techniques have made only minor inroads into the primary biological data–base. Attempts have been made to automate the process in order to achieve an enhanced rate of data–capture to allow access to the larger genome. Progress in instrumenting these techniques has been restricted because of their complexity and the multidisciplinary nature of the procedures involved. This article outlines the manual methods presently employed and reviews current sequencing methodology. A rationale for the possible successful automation of DNA sequencing incorporating a potential for improvements in related areas is presented. Recent sequence instrumentation projects are assessed and an account is provided of contemporary national and international proposals to implement accelerated DNA sequence data–capture.
影响因子：
3.5
作者：
HENIKOFF, S
通讯作者：
HENIKOFF, S