Glucocorticoid hormones and energy homeostasis
Glucocorticoid hormones and energy homeostasis
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DOI：
10.1515/hmbci-2014-0021
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发表时间：
2014-08-01
影响因子：
1
通讯作者：
Herzig, Stephan
中科院分区：
文献类型：
--
作者：
de Guia, Roldan M.;Rose, Adam J.;Herzig, Stephan
糖皮质激素（GC）及其同源细胞内受体糖皮质激素受体（GR）已被认为是哺乳动物能量稳态内分泌控制的关键检查点。事实上，异常的 GC 作用与多种严重的代谢疾病有关，包括肥胖、胰岛素抵抗和 2 型糖尿病。作为转录因子核受体超家族的类固醇结合成员，GR 在 GC 结合后转位到细胞核中，作为不同 GC 响应靶基因的转录调节因子，这些靶基因在许多情况下与葡萄糖和脂质调节途径相关，从而复杂地控制生理和病理生理系统能量稳态。在这里，我们总结了目前关于 GC/GR 在能量代谢和全身代谢功能障碍中的功能的知识，特别关注葡萄糖和脂质代谢。
Glucocorticoids (GC) and their cognate intracellular receptor, the glucocorticoid receptor (GR), have been characterised as critical checkpoints in the endocrine control of energy homeostasis in mammals. Indeed, aberrant GC action has been linked to a variety of severe metabolic diseases, including obesity, insulin resistance and type 2 diabetes. As a steroid-binding member of the nuclear receptor superfamily of transcription factors, the GR translocates into the cell nucleus upon GC binding where it serves as a transcriptional regulator of distinct GC-responsive target genes that are - in many cases - associated with glucose and lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic energy homeostasis. Here, we summarize the current knowledge of GC/GR function in energy metabolism and systemic metabolic dysfunction, particularly focusing on glucose and lipid metabolism.