Early repolarization syndrome: Clinical characteristics and possible cellular and ionic mechanisms
Early repolarization syndrome: Clinical characteristics and possible cellular and ionic mechanisms
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DOI：
10.1054/jelc.2000.18106
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发表时间：
2000-10-01
影响因子：
1.3
通讯作者：
Antzelevitch, C
中科院分区：
文献类型：
--
作者：
Gussak, I;Antzelevitch, C
早期复极综合征（ERS）历来被认为是良性的。在心电图（ECG）中，其特征是st段弥漫性上凸，导联V-2-V-4以正T波结束(5)。由于与高度致心律失常的Brugada综合征的心电图表现相似，并且有误诊的可能性，临床对这种心电图现象的兴趣最近重新燃起。本文讨论了ERS的临床特点和细胞和离子基础。在实验模型中，ERS的心电图特征可以转换为Brugada综合征的心电图特征，这增加了ERS可能不像通常认为的那样是良性的可能性，并且在某些已知易发生st段抬高的条件下，ERS患者可能面临更大的风险。显然需要进一步的临床和实验数据来验证这些假设，并且需要在近年来对Brugada综合征的了解的框架内更充分地描述ERS的特征。
Early repolarization syndrome (ERS) has traditionally been regarded as benign. In the electrocardiogram (ECG), it is characterized by a diffuse upward ST-segment concavity ending in a positive T wave in leads V-2-V-4 (5). Clinical interest in this ECG phenomenon has recently been rekindled because of similarities with the electrocardiographic manifestations of the highly arrhythmogenic Brugada syndrome and the potential for misdiagnosis. This article addresses the clinical characteristics and cellular and ionic basis for ERS. In experimental models, the ECG signature of ERS can be converted to that of the Brugada syndrome, raising the possibility that ERS may not be as benign as generally thought, and that under certain conditions known to predispose to ST-segment elevation, patients with ERS may be at greater risk. Further clinical and experimental data are clearly required to test those hypotheses, and the characteristics of ERS need to be more fully delineated within the framework of what has been learned about the Brugada syndrome in recent years.