EFFECT OF ISOFLAVANS AND ISOFLAVENES ON THE INFECTION OF FRP 3 CELLS BY HEPATITIS-A VIRUS
EFFECT OF ISOFLAVANS AND ISOFLAVENES ON THE INFECTION OF FRP 3 CELLS BY HEPATITIS-A VIRUS
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DOI：
10.1016/0166-3542(89)90034-x
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发表时间：
1989-06-01
影响因子：
7.6
通讯作者：
STEIN, ML
中科院分区：
文献类型：
--
作者：
SUPERTI, F;SEGANTI, L;STEIN, ML
The effect of 6,4''-dichloroflavan and of isoflavan and isoflavene derivatives on hepatitis A virus (HAV) infection in a monkey cell line (Frp/3 cells) was studied. These compounds were not virucidal and had no measurable effect on the adsorption of virus to the cells at 0.degree.C, whereas they exerted an inhibitory effect on viral antigen synthesis when incubated with the infected cells during HAV multiplication. Among the substances tested, 6,4''-dichloroflavan and 6,4''-dichloroisoflavan showed the highest activity. These compounds are postulated to interact with an early stage (penetration and/or uncoating) of HAV infection.
