Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in V1
Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in V1
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DOI：
10.1016/j.neuron.2006.07.028
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发表时间：
2006-10-19
期刊：
影响因子：
16.2
通讯作者：
Chapman, Barbara
中科院分区：
文献类型：
--
作者：
Huberman, Andrew D.;Speer, Colenso M.;Chapman, Barbara
在发育过程中产生眼优势柱(ODC)的机制是有争议的。早期的实验表明，视网膜活动在ODC的形成中起着关键作用。然而，后来的研究表明，在那些早期的实验中，视网膜活动的扰动是在ODCs已经形成之后开始的。此外，最近的研究得出结论，早期摘除眼球不会影响ODC的隔离。在这里，我们在ODC发展的非常早期阶段阻止了自发的视网膜活动。这永久性地扰乱了ODCs的解剖组织，并导致初级视觉皮质中双眼细胞的接受视野显著增加。我们的数据表明，早期自发的视网膜活动传达了关于丘脑皮质轴突代表一侧或另一侧眼睛的关键信息，这一活动介导了双眼竞争，这对形成初级视觉皮质的感受野非常重要。
The mechanisms that give rise to ocular dominance columns (ODCs) during development are controversial. Early experiments indicated a key role for retinal activity in ODC formation. However, later studies showed that in those early experiments, the retinal activity perturbation was initiated afterODCs had already formed. Moreover, recent studies concluded that early eye removals do not impact ODC segregation. Here we blocked spontaneous retinal activity during the very early stages of ODC development. This permanently disrupted the anatomical organization of ODCs and led to a dramatic increase in receptive field size for binocular cells in primary visual cortex. Our data suggest that early spontaneous retinal activity conveys crucial information about whether thalamocortical axons represent one or the other eye and that this activity mediates binocular competition important for shaping receptive fields in primary visual cortex.