Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat
Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat
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周围神经损伤对大鼠蓝斑神经元反应特性及蓝脊髓镇痛的影响
DOI：
10.1016/j.neuroscience.2007.03.016
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发表时间：
2007
期刊：
影响因子：
3.3
通讯作者：
A. Pertovaara
中科院分区：
文献类型：
--
作者：
H. Viisanen;A. Pertovaara
去甲肾上腺素能蓝斑（LC）参与疼痛调节。我们研究了LC神经元或蓝斑脊髓抗伤害感受的反应特性是否在实验性神经病发生后10-14天发生变化。实验在戊巴比妥钠麻醉下在脊神经结扎、假手术和未手术的雄性大鼠中进行。LC神经元的记录表明，伤害性躯体刺激诱发的反应在神经损伤的动物增强，而神经损伤对自发活动或伤害性内脏刺激的反应的影响不显着。杏仁中央核微量注射谷氨酸对神经损伤动物LC神经元的放电率产生了剂量相关的抑制作用，但对对照组的放电率无显着影响。热诱导的后肢退缩潜伏期的评估表明，脊髓抗伤害性刺激诱导的LC是显着较弱的神经损伤比对照组动物。结果表明，周围神经病变引起蓝斑脊髓疼痛抑制的双向变化。LC神经元对伤害性躯体刺激的反应增加可能促进神经性超敏反应的反馈抑制，而来自杏仁核的LC的增强抑制可能抑制去甲肾上腺素能疼痛抑制并促进神经性疼痛。有人建议，减少脊髓直接刺激LC引起的抗伤害性感受可以解释由pronociceptive的变化，在非去甲肾上腺素能系统以前描述的周围神经病变。此外，我们提出的假设，杏仁核处理的情绪增强疼痛，由于增加抑制的LC在周围神经病变。
Noradrenergic locus coeruleus (LC) is involved in pain regulation. We studied whether response properties of LC neurons or coeruleospinal antinociception are changed 10–14 days following development of experimental neuropathy. Experiments were performed in spinal nerve–ligated, sham-operated and unoperated male rats under sodium pentobarbital anesthesia. Recordings of LC neurons indicated that responses evoked by noxious somatic stimulation were enhanced in nerve-injured animals, while the effects of nerve injury on spontaneous activity or the response to noxious visceral stimulation were not significant. Microinjection of glutamate into the central nucleus of the amygdala produced a dose-related inhibition of the discharge rate of LC neurons in nerve-injured animals but no significant effect on discharge rates in control groups. Assessment of the heat-induced hind limb withdrawal latency indicated that spinal antinociception induced by electrical stimulation of the LC was significantly weaker in nerve-injured than control animals. The results indicate that peripheral neuropathy induces bidirectional changes in coeruleospinal inhibition of pain. Increased responses of LC neurons to noxious somatic stimulation are likely to promote feedback inhibition of neuropathic hypersensitivity, while the enhanced inhibition of the LC from the amygdala is likely to suppress noradrenergic pain inhibition and promote neuropathic pain. It is proposed that the decreased spinal antinociception induced by direct stimulation of the LC may be explained by pronociceptive changes in the non-noradrenergic systems previously described in peripheral neuropathy. Furthermore, we propose the hypothesis that emotions processed by the amygdala enhance pain due to increased inhibition of the LC in peripheral neuropathy.
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体细胞刺激从猫脊髓释放单胺：内在调节系统。
DOI：
10.1113/jphysiol.1981.sp013722
发表时间：
1981
期刊：
The Journal of physiology
影响因子：
--
作者：
Tyce,GM;Yaksh,TL
通讯作者：
Yaksh,TL
DOI：
--
发表时间：
1995
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
T. L. Yaksh;J. W. Pogrel;Youn-Woo Lee;S. Chaplan
通讯作者：
T. L. Yaksh;J. W. Pogrel;Youn-Woo Lee;S. Chaplan
影响因子：
2.5
作者：
JONES, SL;GEBHART, GF
通讯作者：
GEBHART, GF
影响因子：
2.5
作者：
PALECEK, J;PALECKOVA, V;WILLIS, WD
通讯作者：
WILLIS, WD