Harmonizing the definition of the metabolic syndrome: Comparison of the Criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations
Harmonizing the definition of the metabolic syndrome: Comparison of the Criteria of the Adult Treatment Panel III and the International Diabetes Federation in United States American and European populations
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DOI：
10.1016/j.amjcard.2006.08.045
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发表时间：
2007-02-15
影响因子：
2.8
通讯作者：
Grundy, Scott M.
中科院分区：
文献类型：
--
作者：
Assmann, Gerd;Guerra, Rudy;Grundy, Scott M.
诊断代谢综合征（MS）的2个最广泛使用的标准是美国国家胆固醇教育计划（ATP 111）成人治疗小组III和国际糖尿病联合会（IDF）制定的标准。这两套标准之间的一个主要区别是，以色列国防军更强调腰围。我们使用ATP III和IDF指南在2个美国（达拉斯健康研究和国家健康和营养检查调查）和1个德国（前瞻性心血管Munster研究）人群样本中比较MS的患病率。当使用ATP III标准时，美国女性（37% vs. 18%）和男性（30% vs. 25%）的MS患病率均高于德国样本，而当使用IDF标准时，德国MS患病率比美国样本高25%。虽然在美国，两套标准确定的大多是相同的人（一致性约为90%），但在德国则不太正确（一致性约为80%）。为了确定哪种标准能更好地预测不良心血管结局，在德国样本（n = 7，152）的中年男性中，比较了10年期间与MS相关的冠状动脉事件的发生率（使用ATP III或IDF标准定义）。共有3.4%的男性没有MS开发的事件。ATP III标准定义的MS男性（10.7%）发生心血管事件的比例远高于IDF标准（5.5%）。总之，尽管在德国样本中使用IDF标准时MS的患病率较高，但IDF标准对冠状动脉事件的预测能力较低。(c)2007年爱思唯尔公司All rights reserved.
The 2 most widely used criteria to diagnose the metabolic syndrome (MS) are those developed by the United States Adult Treatment Panel III of the National Cholesterol Education Program (ATP 111) and by the International Diabetes Federation (IDF). A major difference between these 2 sets of criteria is that the IDF places more emphasis on waist circumference. We compared the prevalence of MS using the ATP III and the IDF guidelines in 2 American (the Dallas Health Study and National Health and Nutrition Examination Survey) and 1 German (Prospective Cardiovascular Munster study) population samples. When the ATP III criteria were used, the prevalence of MS was higher in the United States than the German samples in both women (37% vs. 18%) and men (30% vs 25%), whereas when the IDF criteria were used, the prevalence of MS was 25% higher in the German than the American sample. Although in the United States both sets of criteria identified mostly the same people (concordance of about 90% this was less true in Germany (concordance about 80%). To determine which criteria better predicted adverse cardiovascular outcomes, the incidence of coronary events associated with MS, as defined using the ATP III or the IDF criteria, were compared over a 10-year period among the middle-aged men in the German sample (n = 7,152). A total of 3.4% of men without MS developed an event. A much higher percentage of the men with MS defined by the ATP III criteria (10.7%) than the IDF criteria (5.5%) had a cardiovascular event. In conclusion, although the prevalence of MS was higher when the IDF criteria were used in the German sample, the IDF criteria have lower predictive power for coronary events. (c) 2007 Elsevier Inc. All rights reserved.