Decreased cerebral haemodynamic response to cognitive and physiological tasks in mood disorders as shown by near-infrared spectroscopy
Decreased cerebral haemodynamic response to cognitive and physiological tasks in mood disorders as shown by near-infrared spectroscopy
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DOI：
10.1017/s0033291702005974
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发表时间：
2002-08-01
影响因子：
6.9
通讯作者：
Kato, T
中科院分区：
文献类型：
--
作者：
Matsuo, K;Kato, N;Kato, T
背景资料。通过正电子发射断层扫描等脑功能成像方法，情绪障碍患者的额叶下移已被证实。然而，额叶下垂的神经生物学基础还没有很好地阐明。近红外光谱(NIRS)是一种利用穿透生物组织的近红外光连续监测氧合和脱氧血红蛋白变化的非侵入性技术。我们在认知和生理任务中使用近红外光谱研究了心境障碍患者(重度抑郁障碍和双相情感障碍)患者和对照组额区血红蛋白氧合的变化。在语言流利性任务中，MD组和BP组的OxHb增加明显低于对照组。MD组在过度换气时氧合Hb的下降幅度明显小于对照组。BP组也显示出类似的趋势。这些发现表明，情绪障碍的额叶下垂可能与脑血管对神经元和化学刺激的反应不良有关。
Background. Hypofrontality has been demonstrated in mood disorders by functional brain imaging methods such as positron emission tomography. However, the neurobiological basis of hypofrontality has not been well clarified. Near-infrared spectroscopy (NIRS) is a non-invasive technique for continuous monitoring of alterations in oxygenated (oxyHb) and deoxygenated (deoxyHb) haemoglobin using near-infrared light, which penetrates biological tissues.Methods. We used NIRS during cognitive and physiological tasks to investigate alterations of haemoglobin oxygenation in the frontal region of euthymic patients with mood disorders (major depressive disorder (MD) and bipolar disorder (BP)) and in controls.Results. The increase of oxyHb during a verbal fluency task was significantly less in the MD and the BP groups than in the controls. The MD group showed a significantly smaller decrease of oxyHb during hyperventilation than the controls. The BP group also showed a similar trend.Conclusions. These findings suggest that the hypofrontality in mood disorders may be associated with a poor response in the cerebral blood vessels to neuronal and chemical stimuli.