SYNERGY BETWEEN BASIC FIBROBLAST GROWTH-FACTOR AND HIV-I TAT PROTEIN IN INDUCTION OF KAPOSIS-SARCOMA
SYNERGY BETWEEN BASIC FIBROBLAST GROWTH-FACTOR AND HIV-I TAT PROTEIN IN INDUCTION OF KAPOSIS-SARCOMA
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DOI：
10.1038/371674a0
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发表时间：
1994-10-20
期刊：
影响因子：
64.8
通讯作者：
GALLO, RC
中科院分区：
文献类型：
--
作者：
ENSOLI, B;GENDELMAN, R;GALLO, RC
碱性成纤维细胞生长因子 (bFGF) 和人类免疫缺陷病毒 1 型 (HIV-1) Tat 蛋白协同诱导小鼠血管生成卡波西肉瘤样病变。 Tat 具有协同作用，可响应模拟细胞外基质蛋白的 bFGF 增强内皮细胞生长和 IV 型胶原酶表达。 bFGF、细胞外 Tat 和 Tat 受体存在于 HIV-1 相关 KS 中，这可能解释了与仅存在 bFGF 的经典卡波西肉瘤相比，这种形式的出现频率更高且更具侵袭性。
Basic fibroblast growth factor (bFGF) and human immunodeficiency virus type 1 (HIV-1) Tat protein synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice. Synergy is due to Tat, which enhances endothelial cell growth and type-IV collagenase expression in response to bFGF mimicking extracellular matrix proteins. The bFGF, extracellular Tat and Tat receptors are present in HIV-1-associated KS, which may explain the higher frequency and aggressiveness of this form compared to classical Kaposi's sarcoma where only bFGF is present.