Systems immunogenetics of vaccines.
Systems immunogenetics of vaccines.
复制标题
DOI：
10.1016/j.smim.2013.06.003
复制
发表时间：
2013-04
影响因子：
7.8
通讯作者：
Sékaly RP
中科院分区：
文献类型：
--
作者：
Mooney M;McWeeney S;Sékaly RP
疫苗是预防病毒感染和限制流行病在易感人群中传播的最具成本效益的公共卫生措施。然而，目前的保护性疫苗的效力是高度可变的，特别是在老龄化人群中。此外，由于缺乏对保护的免疫相关性的详细了解，在开发新疫苗方面存在许多挑战。为了确定疫苗免疫反应变异性的机制，需要开发系统级工具，以进一步了解病毒-宿主相互作用和疫苗效力的相关性。这将为合理的疫苗设计提供关键信息，并允许开发一种类似于“精确医学”框架（已被公认为医学和治疗学中的一种强大方法）的方法应用于疫苗学。
Vaccines are the most cost effective public health measure for preventing viral infection and limiting epidemic spread within susceptible populations. However, the efficacy of current protective vaccines is highly variable, particularly in aging populations. In addition, there have been a number of challenges in the development of new vaccines due to a lack of detailed understanding of the immune correlates of protection. To identify the mechanisms underlying the variability of the immune response to vaccines, system-level tools need to be developed that will further our understanding of virus–host interactions and correlates of vaccine efficacy. This will provide critical information for rational vaccine design and allow the development of an analog to the “precision medicine” framework (already acknowledged as a powerful approach in medicine and therapeutics) to be applied to vaccinology.
登录
查看更多内容
影响因子：
30.8
作者：
Jallow, Muminatou;Teo, Yik Ying;Small, Kerrin S.;Rockett, Kirk A.;Deloukas, Panos;Clark, Taane G.;Kivinen, Katja;Bojang, Kalifa A.;Conway, David J.;Pinder, Margaret;Sirugo, Giorgio;Sisay-Joof, Fatou;Usen, Stanley;Auburn, Sarah;Bumpstead, Suzannah J.;Campino, Susana;Coffey, Alison;Dunham, Andrew;Fry, Andrew E.;Green, Angela;Gwilliam, Rhian;Hunt, Sarah E.;Inouye, Michael;Jeffreys, Anna E.;Mendy, Alieu;Palotie, Aarno;Potter, Simon;Ragoussis, Jiannis;Rogers, Jane;Rowlands, Kate;Somaskantharajah, Elilan;Whittaker, Pamela;Widden, Claire;Donnelly, Peter;Howie, Bryan;Marchini, Jonathan;Morris, Andrew;SanJoaquin, Miguel;Achidi, Eric Akum;Agbenyega, Tsiri;Allen, Angela;Amodu, Olukemi;Corran, Patrick;Djimde, Abdoulaye;Dolo, Amagana;Doumbo, Ogobara K.;Drakeley, Chris;Dunstan, Sarah;Evans, Jennifer;Farrar, Jeremy;Fernando, Deepika;Hien, Tran Tinh;Horstmann, Rolf D.;Ibrahim, Muntaser;Karunaweera, Nadira;Kokwaro, Gilbert;Koram, Kwadwo A.;Lemnge, Martha;Makani, Julie;Marsh, Kevin;Michon, Pascal;Modiano, David;Molyneux, Malcolm E.;Mueller, Ivo;Parker, Michael;Peshu, Norbert;Plowe, Christopher V.;Puijalon, Odile;Reeder, John;Reyburn, Hugh;Riley, Eleanor M.;Sakuntabhai, Anavaj;Singhasivanon, Pratap;Sirima, Sodiomon;Tall, Adama;Taylor, Terrie E.;Thera, Mahamadou;Troye-Blomberg, Marita;Williams, Thomas N.;Wilson, Michael;Kwiatkowski, Dominic P.
通讯作者：
Kwiatkowski, Dominic P.
影响因子：
4.5
作者：
Fellay J;Ge D;Shianna KV;Colombo S;Ledergerber B;Cirulli ET;Urban TJ;Zhang K;Gumbs CE;Smith JP;Castagna A;Cozzi-Lepri A;De Luca A;Easterbrook P;Günthard HF;Mallal S;Mussini C;Dalmau J;Martinez-Picado J;Miro JM;Obel N;Wolinsky SM;Martinson JJ;Detels R;Margolick JB;Jacobson LP;Descombes P;Antonarakis SE;Beckmann JS;O'Brien SJ;Letvin NL;McMichael AJ;Haynes BF;Carrington M;Feng S;Telenti A;Goldstein DB;NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
通讯作者：
NIAID Center for HIV/AIDS Vaccine Immunology (CHAVI)
影响因子：
3.7
作者：
Lingappa JR;Petrovski S;Kahle E;Fellay J;Shianna K;McElrath MJ;Thomas KK;Baeten JM;Celum C;Wald A;de Bruyn G;Mullins JI;Nakku-Joloba E;Farquhar C;Essex M;Donnell D;Kiarie J;Haynes B;Goldstein D;Partners in Prevention HSV/HIV Transmission Study Team
通讯作者：
Partners in Prevention HSV/HIV Transmission Study Team
影响因子：
3.8
作者：
Lee, Eva K.
通讯作者：
Lee, Eva K.
影响因子：
5.2
作者：
Franzosa EA;Garamszegi S;Xia Y
通讯作者：
Xia Y