Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.
Emerging nanotechnology approaches for HIV/AIDS treatment and prevention.
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DOI：
10.2217/nnm.10.1
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
Farokhzad OC
中科院分区：
文献类型：
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作者：
Mamo T;Moseman EA;Kolishetti N;Salvador-Morales C;Shi J;Kuritzkes DR;Langer R;von Andrian U;Farokhzad OC
目前，艾滋病毒/艾滋病没有治愈方法，也没有预防疫苗。联合抗逆转录病毒疗法极大地改善了治疗效果，但它必须终生服用，具有重大副作用，并且对病毒产生耐药性的患者无效。纳米技术是一个新兴的多学科领域，是革命性的医学在21世纪世纪。它具有极大的潜力，可从根本上推动艾滋病毒/艾滋病的治疗和预防。在这篇综述中，我们讨论了目前治疗这种疾病的挑战，并阐明了纳米技术的巨大潜力，通过推进抗逆转录病毒疗法，基因疗法，免疫疗法，疫苗学和杀微生物剂，为艾滋病毒/艾滋病提供更有效的治疗和预防。
Currently, there is no cure and no preventive vaccine for HIV/AIDS. Combination antiretroviral therapy has dramatically improved treatment, but it has to be taken for a lifetime, has major side effects and is ineffective in patients in whom the virus develops resistance. Nanotechnology is an emerging multidisciplinary field that is revolutionizing medicine in the 21st century. It has a vast potential to radically advance the treatment and prevention of HIV/AIDS. In this review, we discuss the challenges with the current treatment of the disease and shed light on the remarkable potential of nanotechnology to provide more effective treatment and prevention for HIV/AIDS by advancing antiretroviral therapy, gene therapy, immunotherapy, vaccinology and microbicides.