Autologous Platelet Rich Plasma: Topical Versus Intradermal After Fractional Ablative Carbon Dioxide Laser Treatment of Atrophic Acne Scars
Autologous Platelet Rich Plasma: Topical Versus Intradermal After Fractional Ablative Carbon Dioxide Laser Treatment of Atrophic Acne Scars
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DOI：
10.1111/dsu.12392
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发表时间：
2014-02-01
影响因子：
2.4
通讯作者：
Fathy, Marwa
中科院分区：
文献类型：
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作者：
Gawdat, Heba I.;Hegazy, Rehab A.;Fathy, Marwa
背景最近提出了关于富血小板血浆（PRP）联合点阵二氧化碳激光（FCL）辅助治疗痤疮疤痕的建议。 目的 比较 FCL 后自体 PRP 两种给药方式（皮内注射（ID）和局部应用）与单独使用 FCL 治疗萎缩性痤疮疤痕的疗效和安全性。 患者与方法 将 30 例患者随机分为两组。两人都接受了裂脸疗法。第1组一侧先施用FCL，然后施用ID PRP，另一侧施用FCL，然后施用ID盐水。在第2组中，一侧脸颊接受FCL治疗，随后进行ID PRP治疗，另一侧脸颊接受FCL治疗，随后接受局部PRP治疗。每位患者接受 3 个月的疗程。最终评估在 6 个月时进行。结果 与 FCL 治疗区域相比，PRP 和 FCL 联合治疗区域的反应明显更好（p = .03），副作用更少，恢复时间更短（p = .02），但 ID 和局部 PRP 治疗区域在反应程度和恢复时间方面没有显着差异（p = .10）；局部治疗区域的疼痛评分显着降低。 结论 目前的研究介绍了局部 PRP 和 FCL 的组合作为治疗萎缩性痤疮疤痕的一种有效、安全的方式，其恢复时间比单独使用 FCL 更短，并且比 FCL 联合 ID PRP 具有更好的耐受性。
BACKGROUND A proposal has recently been made regarding the potential adjuvant use of platelet-rich plasma (PRP) with fractional carbon dioxide laser (FCL) for the correction of acne scars.OBJECTIVE To compare the efficacy and safety of two administration modes of autologous PRP (intradermal injection (ID) and topical application) after FCL with that of FCL alone in the treatment of atrophic acne scars.PATIENTS AND METHODS Thirty patients were randomly divided into two groups. Both underwent split-face therapy. Group 1 was administered FCL followed by ID PRP on one side and FCL followed by ID saline on the other. In group 2, one cheek was treated with FCL followed by ID PRP, and the other received FCL followed by topical PRP. Each patient received 3 monthly sessions. The final assessment took place at 6 months.RESULTS Combined PRP- and FCL-treated areas had a significantly better response (p = .03), fewer side effects, and shorter downtime (p = .02) than FCL-treated areas, but there were no significant differences in ID- and topical PRP-treated areas in degree of response and downtime (p = .10); topically treated areas had significantly lower pain scores.CONCLUSION The current study introduces the combination of topical PRP and FCL as an effective, safe modality in the treatment of atrophic acne scars with shorter downtime than FCL alone and better tolerability than FCL combined with ID PRP.