Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration.

Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration.
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DOI:
10.3389/fphys.2020.583393
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发表时间:
2020
影响因子:
4
通讯作者:
Lee PHU
Lee PHU
中科院分区:
医学2区
文献类型:
--
作者:
Benissan-Messan DZ;Zhu H;Zhong W;Tan T;Ma J;Lee PHU

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自2009年发现以来,多项研究表明MG 53在肌肉生理学中的重要性。这种蛋白质在横纹肌中产生,但具有超出横纹肌范围的生理意义。在肌肉再生、钙稳态、兴奋-收缩偶联、肌生成和线粒体中的作用突出了蛋白质的广泛影响。许多治疗应用可能从这些生理作用中产生。本文综述了目前有关MG 53在骨骼肌中作用的文献。治疗应用进行了讨论。
Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.
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