Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration.
Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration.
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DOI:
10.3389/fphys.2020.583393
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发表时间:
2020
影响因子:
4
通讯作者:
Lee PHU
中科院分区:
文献类型:
--
作者:
Benissan-Messan DZ;Zhu H;Zhong W;Tan T;Ma J;Lee PHU
Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles. Roles in muscle regeneration, calcium homeostasis, excitation-contraction coupling, myogenesis, and the mitochondria highlight the protein’s wide-reaching impact. Numerous therapeutic applications could potentially emerge from these physiologic roles. This review summarizes the current literature regarding the role of MG53 in the skeletal muscle. Therapeutic applications are discussed.
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