Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics
Prepulse inhibition of the startle response in risperidone-treated patients: comparison with typical antipsychotics
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DOI：
10.1016/s0920-9964(01)00276-6
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发表时间：
2002-05-01
影响因子：
4.5
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Kumari, V;Soni, W;Sharma, T
众所周知，精神分裂症患者在惊吓反应的脉冲前抑制(PPI)方面表现出缺陷，PPI指的是对强烈的令人震惊的刺激的反应抑制，如果在此之前短暂地出现弱的非令人震惊的刺激，则PPI代表了一个成熟的动物模型来研究精神分裂症的信息处理缺陷。这项研究使用自然主义的受试者间设计，检查了服用典型抗精神病药物或第二代非典型抗精神病药物利培酮的精神分裂症患者的惊恐声反应的PPI。对两组男性精神分裂症患者：(I)服用一系列典型抗精神病药物(n=20)和(Ii)服用利培酮(n=10)稳定的男性精神分裂症患者进行了PPI(脉冲前-脉冲间期：30、60和120ms，前脉冲高于背景15分贝)的测试。并与健康男性受试者(n=20)进行比较。服用典型抗精神病药物的患者在30ms和60ms脉冲前试验中的PPI显著低于健康受试者。在任何脉冲前试验中，利培酮治疗的患者的PPI与健康受试者没有区别。现在需要进一步的纵向受试者内研究，以检查利培酮在改善信息处理功能方面是否优于典型的抗精神病药物，这是通过对治疗敏感的男性精神分裂症患者的声学惊吓反应的PPI来评估的。(C)2002 Elsevier Science B.V.保留所有权利。
Individuals with schizophrenia are known to show deficits in prepulse inhibition (PPI) of the startle response, PPI refers to a response suppression in reaction to a strong startling stimulus, if preceded briefly by a weak non-startling stimulus and represents a well-established animal model to investigate information processing deficits in schizophrenia. This study examined PPI of the startle acoustic response in schizophrenic patients given typical antipsychotics or a second generation atypical antipsychotic, risperidone, using a naturalistic between-subjects design. Two groups of male schizophrenic patients: (i) stable on a range of typical antipsychotics (n = 20), and (ii) stable on risperidone (n = 10) were tested for PPI (prepulse-to-pulse intervals: 30, 60, and 120 ms, prepulses 15 dB above the background) of the acoustic startle response. and compared with a group of healthy male subjects (n = 20). Patients on typical antipsychotics showed significantly less PPI with 30 and 60 ms prepulse trials than healthy subjects. Risperidone-treated patients did not differ from healthy subjects for PPI with any prepulse trials. Further longitudinal within-subject studies are now,, required to examine whether risperidone is superior to typical antipsychotics in improving information processing functions, as assessed by PPI of the acoustic startle response, in treatment-responsive male patients with schizophrenia. (C) 2002 Elsevier Science B.V. All rights reserved.