ENHANCED ORAL ABSORPTION OF INSULIN FROM DESOLVATED FATTY-ACID SODIUM GLYCOCHOLATE EMULSIONS
ENHANCED ORAL ABSORPTION OF INSULIN FROM DESOLVATED FATTY-ACID SODIUM GLYCOCHOLATE EMULSIONS
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DOI：
10.1016/0378-5173(94)90343-3
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发表时间：
1994-10-27
影响因子：
5.8
通讯作者：
VEJOSOTH, S
中科院分区：
文献类型：
--
作者：
MESIHA, M;PLAKOGIANNIS, F;VEJOSOTH, S
使用胆汁盐作为乳化剂和吸收促进剂制备胰岛素在脂肪酸中的脂质分散体。含胰岛素-甘氨胆酸钠组合的口服去溶剂化乳剂显示出不同的降血糖作用，取决于所用的脂肪酸。棕榈酸系统，含有5 U胰岛素/50毫克分散体每公斤兔体重，导致在30分钟内从105到75毫克/分升的血糖降低。效果延长超过150分钟，与非脂肪酸系统的统计学显着差异。不饱和脂肪酸没有表现出与相同碳链长度的饱和脂肪酸相同的增强效果。
Lipoidal dispersions of insulin in fatty acids were prepared using a bile salt as an emulsifier and as absorption promoter. The orally administered desolvated emulsions containing insulin-sodium glycocholate combinations showed different hypoglycemic effects depending on the fatty acid used. A palmitic acid system, containing 5 U insulin/50 mg dispersion per kg rabbit weight, resulted in the reduction of blood glucose from 105 to 75 mg/dl in 30 min. The effect extended over 150 min with statistically significant difference from non-fatty acid systems. Unsaturated fatty acids did not show the same enhancing effect as saturated fatty acids of the same carbon chain length.