Engineering Biofunctional Enzyme-Mimics for Catalytic Therapeutics and Diagnostics
Engineering Biofunctional Enzyme-Mimics for Catalytic Therapeutics and Diagnostics
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DOI：
10.1002/adfm.202007475
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发表时间：
2020-11-02
影响因子：
19
通讯作者：
Cheng, Chong
中科院分区：
文献类型：
--
作者：
Tang, Qing;Cao, Sujiao;Cheng, Chong
纳米材料模拟酶在生物催化治疗和诊断领域的应用引起了广泛关注。调控酶制剂的生物催化性能和生物功能是重要的研究目标，包括合理设计和合成具有所需生物功能的分子和纳米结构的酶制剂，特别是在分子甚至单原子水平上。在这里，这个及时的进展报告提供了关键的进展和评论的工程生物功能酶-Ms（BF/Enz-Ms）的最新研究，特别是化学合成，功能化策略，BF/Enz-Ms的不同酶模拟催化活性的集成。然后，详细的评论和讨论的制造协议，生物催化性能，和治疗/诊断应用工程BF/Enz-Ms通过水凝胶，纳米凝胶，金属有机框架，金属多酚网络，共价有机框架，功能细胞膜，生物活性分子和聚合物，和复合材料。最后，对BF/Enz-MS的未来前景和挑战进行了概述和深入讨论。相信本进展报告将对BF/Enz-Ms的最新设计原理进行化学和材料概述，从而进一步促进其未来的发展和广泛应用的性能。
The applications of nanomaterial-based enzyme-mimics (Enz-Ms) in biocatalytically therapeutic and diagnostic fields have attracted extensive attention. The regulation of the biocatalytic performances and biofunctionalities of Enz-Ms are essential research objectives, including the rational design and synthesis of Enz-Ms with desired biofunctional molecules and nanostructures, especially at the level of molecules and even single atoms. Here, this timely progress report provides pivotal advances and comments on recent researches on engineering biofunctional Enz-Ms (BF/Enz-Ms), particularly chemical synthesis, functionalization strategies, and integration of diverse enzyme-mimetic catalytic activities of BF/Enz-Ms. First, the definitions and catalogs of BF/Enz-Ms are briefly introduced. Then, detailed comments and discussions are provided on the fabrication protocols, biocatalytic properties, and therapeutic/diagnostic applications of engineered BF/Enz-Ms via hydrogels, nanogels, metal-organic frameworks, metal-polyphenol networks, covalent-organic frameworks, functional cell membranes, bioactive molecules and polymers, and composites. Finally, the future perspectives and challenges on BF/Enz-Ms are outlined and thoroughly discussed. It is believed that this progress report will give a chemical and material overview on the state-of-the-art designing principles of BF/Enz-Ms, thus further promoting their future developments and prosperities for a wide range of applications.