"Let there be light": the role of vitamin D in the immune response to vaccines.
"Let there be light": the role of vitamin D in the immune response to vaccines.
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DOI：
10.1586/14760584.2015.1082426
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发表时间：
2015
影响因子：
6.2
通讯作者：
Poland GA
中科院分区：
文献类型：
--
作者：
Sadarangani SP;Whitaker JA;Poland GA
维生素D的非骨骼作用，包括免疫调节作用，已越来越多地得到认可。重要的是，许多免疫细胞能够从循环的25-（OH）D合成生物活性形式的维生素D，随后进行内分泌作用，并且维生素D受体（VDR）广泛分布。在这篇综述中，我们讨论了维生素D在先天性和适应性免疫反应中的有效作用，并发表了评估血清维生素D、维生素D基因通路多态性或经验性维生素D补充剂对疫苗免疫原性影响的研究。我们强调了现有的知识差距，并提出了推进科学所需的步骤，并回答了维生素D是否可以证明作为某些传染病疫苗的疫苗佐剂有价值的问题。
Vitamin D’s non-skeletal actions, including immunomodulatory role, have been increasingly recognized. Of significance, many immune cells are able to synthesize a biologically active form of vitamin D from circulating 25-(OH) D with subsequent intracrine actions, and the vitamin D receptor (VDR) is broadly distributed. In this review, we discuss vitamin D’s potent role in innate and adaptive immune responses and published studies evaluating the impact of serum vitamin D, vitamin D gene pathway polymorphisms or empiric vitamin D supplementation on vaccine immunogenicity. We highlight existing knowledge gaps and propose the steps needed to advance the science and answer the question of whether vitamin D may prove valuable as a vaccine adjuvant for certain vaccines against infectious diseases.