Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes.
Advances in glioma models using in vivo electroporation to highjack neurodevelopmental processes.
复制标题
DOI：
10.1016/j.bbcan.2023.188951
复制
发表时间：
2023-07
期刊：
影响因子：
--
通讯作者：
Longbo Zhang;A. Bordey
中科院分区：
文献类型：
--
作者：
Longbo Zhang;A. Bordey
神经胶质瘤是最常见的神经系统恶性肿瘤。尽管在神经外科、化疗和放射治疗方面做了几十年的努力，神经胶质瘤仍然是最耐药的脑肿瘤之一，预后不佳。基因组和表观遗传学的最新进展揭示了人类胶质瘤病因学中涉及的遗传事件的新概念，同时，基因编辑和传递方面的革命性技术允许在动物中编码这些遗传事件，以对胶质瘤模型进行基因工程。这种方法在具有完整免疫系统的自然微环境中模拟胶质瘤的发生和发展，并促进探索性治疗策略。在这篇综述中，我们重点介绍了基于活体电穿孔的胶质瘤模型的最新进展，并概述了已建立的基因工程胶质瘤模型(GEGM)。
Glioma is the most prevalent type of neurological malignancies. Despite decades of efforts in neurosurgery, chemotherapy and radiation therapy, glioma remains one of the most treatment-resistant brain tumors with unfavorable outcomes. Recent progresses in genomic and epigenetic profiling have revealed new concepts of genetic events involved in the etiology of gliomas in humans, meanwhile, revolutionary technologies in gene editing and delivery allows to code these genetic “events” in animals to genetically engineer glioma models. This approach models the initiation and progression of gliomas in a natural microenvironment with an intact immune system and facilitates probing therapeutic strategies. In this review, we focus on recent advances inin vivoelectroporation-based glioma modeling and outline the established genetically engineered glioma models (GEGMs).