The Effects of Social Experience and Gonadal Hormones on Retrieving Behavior of Mice and their Responses to Pup Ultrasonic Vocalizations
The Effects of Social Experience and Gonadal Hormones on Retrieving Behavior of Mice and their Responses to Pup Ultrasonic Vocalizations
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DOI：
10.2108/zsj.27.790
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发表时间：
2010-10-01
影响因子：
0.9
通讯作者：
Kikusui, Takefumi
中科院分区：
文献类型：
--
作者：
Okabe, Shota;Nagasawa, Miho;Kikusui, Takefumi
幼鼠超声波发声（USV）是从母鼠分离的幼鼠发出的，被认为是引发小鼠母性行为的触发因素。我们研究了社会经验和性腺切除对小鼠检索行为的影响，以及它们对纳米晶硅热声发射器产生的幼鼠USV的反应。在每个实验中，处女，gonadectomized，假手术，性经验，和父母的两种性别的小鼠，这些操作的影响进行了比较，在每种性别。两性的检索行为随着社会经验或性腺切除而增加。特别是，母亲表现出最高的检索活动在女性群体中，而去势雄性小鼠表现出最高的检索活动在男性群体中。所有组的雌性小鼠对幼鼠USV都有反应，其中有性经验的雌性小鼠的反应性最强。与雌性不同，处女雄性小鼠对幼崽USV没有反应，尽管有社交经验或阉割的雄性小鼠表现出这种反应;父亲表现出最高的反应。这些结果表明，不仅养育经验，而且交配经验，可能会提高检索活动和反应的小狗USVs在两种性别的小鼠。然而，在何种程度上，父母的经验有助于提高这两个活动的性别之间的差异。此外，性腺切除术增强了这两种活动在两种性别，虽然其效果更突出的男性。总的来说，我们的研究结果表明，小鼠对幼鼠USV的反应性改变可能是由社会经验或性腺激素引起的父母行为变化之一。
Pup ultrasonic vocalizations (USVs) are emitted from maternally separated pups and are thought to be a trigger for eliciting maternal behavior in mice. We investigated the effects of social experience and gonadectomy on the retrieving behavior of mice and their responses to pup USVs produced by a nanocrystalline silicon thermo-acoustic emitter. In each experiment, virgin, gonadectomized, sham-operated, sexually experienced, and parenting mice of both sexes were used, and the effects of these manipulations were compared in each sex. The retrieving behavior of both sexes increased with social experience or gonadectomy. In particular, mothers showed the highest retrieving activity among female groups, while castrated male mice showed the highest retrieving activity among male groups. All groups of female mice responded to pup USVs, with the responsiveness of sexually experienced female mice being the most enhanced. Unlike the females, virgin male mice did not respond to pup USVs, although socially experienced or castrated males showed this response; fathers exhibited the highest responsiveness. These results suggest that not only parenting experience, but also mating experience, may enhance retrieving activity and response to pup USVs in mice of both sexes. Nevertheless, the degree to which parenting experience contributed to the enhancement of both activities differed between the sexes. Furthermore, gonadectomy enhanced both activities in both sexes, although its effect was more prominent in males. Overall, our findings suggest that alteration in responsiveness of mice to pup USVs might be one of the changes in parental behavior caused by social experiences or gonadal hormones.