SALTS OF DECAMETHYLENE-BIS-4-AMINOQUINALDINIUM (DEQUADIN) A NEW ANTIMICROBIAL AGENT
SALTS OF DECAMETHYLENE-BIS-4-AMINOQUINALDINIUM (DEQUADIN) A NEW ANTIMICROBIAL AGENT
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DOI：
10.1111/j.2042-7158.1956.tb12138.x
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发表时间：
1956-01-01
影响因子：
3.3
通讯作者：
TAYLOR, EP
中科院分区：
文献类型：
--
作者：
BABBS, M;COLLIER, HOJ;TAYLOR, EP
这些作者一直在研究一系列相关化合物的抗菌性能，其中十亚甲基-双-4-氨基喹哪啶（Dequadin）被证明是最有前途的：在不同的实验中使用了这种物质的几种不同溶解度的盐。它在极低浓度下对大多数革兰氏阳性菌、分枝杆菌和真菌具有抑菌作用，但对革兰氏阴性菌的活性较低：血清不影响这种作用。它还具有杀菌作用。当Dequadin与各种抗生素或西曲溴铵混合时，获得加和效应。它的静脉注射LD 50仅为1.9 mgm。每千克，这些动物似乎死于呼吸麻痹。皮下或口服给药耐受性更好，各种形式的局部应用也是如此。腹腔内接种链球菌或葡萄球菌的小鼠，30分钟后通过相同途径注射药物可以挽救其生命：这被认为是局部效应。希望Dequadin可以被证明是一种具有临床价值的“局部化疗剂”。P。加罗德。
These authors have been examining the antibacterial properties of a series of related compounds, of which decamethylene-bis-4-aminoquinaldinium (Dequadin) proved to be the most promising: several salts of this substance of varying solubility were used in different experiments. It is bacteriostatic in very low concentrations for most Gram-positive bacteria and for mycobacteria and fungi, but less active against Gram-negative organisms: serum does not affect this action. It is also bactericidal. Additive effects were obtained when Dequadin was mixed with various antibiotics or cetrimide. It has an intravenous LD50 of only 1.9 mgm. per kgm., the animals appearing to die of respiratory paralysis. Subcutaneous or oral administration was better tolerated, as were various forms of local application. The lives of mice inoculated intra-peritoneally with streptococci or staphylococci could be saved by injecting the drug by the same route 30 minutes later: this is recognized as being a local effect. Hopes are entertained that Dequadin may prove to be of clinical value as a " local chemotherapeutic agent".L. P. Garrod.