Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations.
Organophosphate pesticides exposure in pregnant women and maternal and cord blood thyroid hormone concentrations.
复制标题
孕妇接触有机磷农药以及母体和脐带血甲状腺激素浓度。
DOI：
10.1016/j.envint.2019.105124
复制
发表时间：
2019
影响因子：
11.8
通讯作者：
Tiemeier,Henning
中科院分区：
文献类型：
--
作者：
Mulder,TessaA;vandenDries,MichielA;Korevaar,TimIM;Ferguson,KellyK;Peeters,RobinP;Tiemeier,Henning
背景动物研究表明，有机磷（OP）农药暴露影响甲状腺功能，但在人类的证据仍然稀少和不确定。由于甲状腺激素是胎儿大脑发育所必需的，因此，对甲状腺素的暴露尤其令人感兴趣。OP农药能够穿过胎盘和血脑屏障，并可能干扰胎儿发育过程中调节甲状腺hormone. Objectiveinvestigate妊娠期OP农药暴露在怀孕期间与母亲和脐带血甲状腺激素concentrations.MethodsThis研究嵌入一代R（鹿特丹，荷兰），一个前瞻性的人口为基础的出生队列。纳入了具有OP农药评估和母亲（N= 715）或脐带血（N= 482）甲状腺激素测量的母子对。在妊娠<18周、18-25周和>25周时，通过测量尿中的六种二烷基磷酸盐（DAP）代谢物来评估OP农药暴露。测定母血和脐血促甲状腺激素（TSH）和游离甲状腺素（FT 4）。母体测量还包括总甲状腺素（TT 4）和TPO抗体（TPOAbs）。要研究肌酸酐调整DAP代谢物浓度与甲状腺功能和TPO抗体的关联，多变量线性回归模型，包括相关的混杂因素used.ResultsThere是没有关联的DAP代谢物与母亲的TSH，FT 4，TT 4或TPOAb浓度在怀孕期间。同样，DAP代谢产物与脐带血TSH或FT 4也无相关性。结果并没有改变时，DAP浓度进行分析，在个别时间点或平均妊娠exposition. ConclusionGeetherOP农药暴露，反复测量尿中DAP代谢物浓度在城市人群中进行评估，是不相关的母亲或脐带血甲状腺激素浓度。这些研究结果不支持血清甲状腺激素可用性的关系，早期生活暴露于低水平的OP农药与儿童神经发育的中介作用。然而，不能排除甲状腺系统在组织水平上的破坏。此外，这是关于该主题的首批研究之一，DAP代谢物的测量误差可能导致估计不精确。未来的研究应使用更多的尿液样本，以提高精度，并应调查特定的OP农药代谢物。
BackgroundAnimal studies suggest that organophosphate (OP) pesticides exposure affects thyroid function, but evidence in humans remains sparse and inconclusive. Gestational exposure is of particular interest, since thyroid hormone is essential for fetal brain development. OP pesticides are able to cross the placental and blood-brain barrier and may interfere with fetal development processes regulated by thyroid hormone.ObjectiveTo investigate the association of gestational OP pesticides exposure during pregnancy with maternal and cord blood thyroid hormone concentrations.MethodsThis study was embedded within Generation R (Rotterdam, the Netherlands), a prospective population-based birth cohort. Mother-child pairs with OP pesticides assessment and maternal (N= 715) or cord blood (N= 482) thyroid hormone measurements were included. OP pesticides exposure was assessed at <18, 18–25, and >25 weeks gestation by measuring six urinary dialkylphosphate (DAP) metabolites. Thyroid stimulating hormone (TSH) and free thyroxine (FT4) were measured in maternal and cord blood. Maternal measures also included total thyroxine (TT4) and TPO antibodies (TPOAbs). To study the association of creatinine-adjusted DAP metabolite concentrations with thyroid function and TPO antibodies, multivariable linear regression models including relevant confounders were used.ResultsThere was no association of DAP metabolites with maternal TSH, FT4, TT4 or TPOAb concentrations during pregnancy. Similarly, there was no association of DAP metabolites with cord blood TSH or FT4. Results did not change when DAP concentrations were analyzed at individual time points or as mean gestational exposure.ConclusionGestational OP pesticides exposure, as assessed by repeatedly measured urinary DAP metabolite concentrations in an urban population, was not associated with maternal or cord blood thyroid hormone concentrations. These findings do not support a mediating role for serum thyroid hormone availability in the relation of early life exposure to low levels of OP pesticides with child neurodevelopment. However, disruption of the thyroid system at tissue level cannot be excluded. In addition, this is one of the first studies on this subject and measurement error in DAP metabolites might have resulted in imprecise estimates. Future studies should use more urine samples to increase precision and should investigate specific OP pesticide metabolites.