Morphological and Histological Changes in the Mandibular Condyle after Plate Removal in Experimental Models of Short- and Long-term Mandibular Lateral Displacement
Morphological and Histological Changes in the Mandibular Condyle after Plate Removal in Experimental Models of Short- and Long-term Mandibular Lateral Displacement
复制标题
短期和长期下颌横向位移实验模型中钢板去除后下颌髁突的形态学和组织学变化
DOI：
10.2485/jhtb.22.201
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发表时间：
2013
影响因子：
0.4
通讯作者：
K. Kasai
中科院分区：
文献类型：
--
作者：
Junji Ando;M. Yamaguchi;Shouji Fujita;Aya Kawamura;T. Utsunomiya;K. Kasai
我们进行了一项体内研究，以阐明下颌骨和髁突的力学在儿童下颌骨功能性偏斜患者。我们在实验中造成了横向位移的下颌骨在4周龄大鼠的牙齿连接板4（短期组：ST组）或12周（长期组：LT组），并用免疫组织化学方法观察基质金属蛋白酶-1（MMP-1）、血管内皮生长因子（VEGF）、和结缔组织生长因子（CTGF）的作用，探讨髁突形态恢复过程中软骨基质组成的变化。此外，使用微（μ）-CT观察形态。取出接骨板后，两组MMP-1的表达均显著降低。ST组VEGF和CTGF表达较LT组明显增加。在形态测量学方面，两组患者在去除后即刻均观察到下颌骨不对称和髁状突畸形。与LT组相比，ST组的下颌骨形态明显恢复。这表明早期咬合异常的矫正可以恢复正常的下颌骨形态。
: We conducted an in vivo study to clarify the mechanics of the mandibular bone and condyles in pediatric patients with mandibular functional deviation. We experimentally caused lateral displacement of the mandible in 4-week-old rats by attaching a plate to the teeth for 4 (short-term group: ST group) or 12 weeks (long-term group: LT group), and immunohistochemically investigated the pattern of appearance of matrix metalloproteinase-1 (MMP-1), vascular endothelial growth factor (VEGF), and connective tissue growth factor (CTGF) to investigate the changes in the cartilage matrix constitution during the recovery of the condylar morphology. Furthermore, the morphology was observed using micro (μ) -CT. After plate removal, the MMP-1 expression significantly decreased in the both groups. Furthermore the expressions of VEGF and CTGF were increased in the ST group compared to those observed in the LT group. In terms of the morphometry, mandibular asymmetry and deformity of the condyle were noted immediately after removal in the both groups. The mandibular morphology markedly recovered in the ST group compared to that in the LT group. This indicates that correction of occlusal abnormalities during an early stage leads to recovery of the normal mandibular configuration.
混合矫治器：牙面矫形的一种组件方法。
DOI：
10.1016/0889-5406(86)90084-3
发表时间：
1986
期刊：
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
影响因子：
--
作者：
Vig,PS;Vig,KW
通讯作者：
Vig,KW