No-Carrier-Added Radiohalogenation Methods with Heavy Halogens
No-Carrier-Added Radiohalogenation Methods with Heavy Halogens
复制标题
无载流子添加的重卤素放射性卤化方法
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
G. Stöcklin
中科院分区：
文献类型：
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作者：
H. Coenen;S. Moerlein;G. Stöcklin
本文综述了溴、碘、<$3种重卤素的放射性标记方法。这些方法的基础上，其基本的化学原理和它们的有用性的生物有用的化合物的无载体添加标记进行评估。特别强调的是放在稳定性，比活性，和质量控制的放射性卤化产品使用短寿命，缺中子核素7 s ' 7 ' B r，'“I，和2“鉴于其重要性作为放射性药物。
Radiolabeling methods with the heavy halogens bromine, iodine and astatine are reviewed. The methods are evaluated on the basis of their underlying chemical principles and their usefulness for the no-carrier-added labeling of biologically-useful compounds. Special emphasis is placed on the stability, specific activity, and quality control of radiohalogenation products using the shortlived, neutron-deficient nuclides 7 s ' 7 ' B r , ' " I , and 2 " A t in view of their importance as radiopharmaceuticals.