Effects of sensory behavioral tasks on pain threshold and cortical excitability.
Effects of sensory behavioral tasks on pain threshold and cortical excitability.
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DOI：
10.1371/journal.pone.0052968
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Fregni F
中科院分区：
文献类型：
--
作者：
Volz MS;Suarez-Contreras V;Mendonca ME;Pinheiro FS;Merabet LB;Fregni F
经皮电刺激已被证明可以调节神经系统活动，通过外周感觉系统以自下而上的方式导致疼痛感知的变化。我们测试了不同的感觉行为任务是否会对疼痛加工产生显著影响，以及这些变化是否与皮质可塑性相关。这项随机平行设计的实验包括40名健康的右撇子男性。采用经颅磁刺激（TMS）测试了三种不同的体感任务，包括有视觉反馈和无视觉反馈的学习任务和简单的体感输入，对压力痛阈值和运动皮层兴奋性进行了测试。感官任务诱导手部特异性疼痛调节效应。他们提高了左手的疼痛阈值（这是感官任务的目标），降低了右手的疼痛阈值。经颅磁刺激显示躯体感觉输入降低了皮质兴奋性，表现为MEP振幅降低和SICI增加。尽管躯体感觉任务同样改变了疼痛阈值和皮质兴奋性，但这些变量之间没有显著的相关性，只有视觉反馈任务显示出显著的躯体感觉学习。皮层兴奋性和疼痛阈值之间缺乏相关性，也缺乏不同任务间的差异效应，但疼痛阈值的显著变化表明，体感觉任务的镇痛作用主要与运动皮质神经机制无关，因此，表明皮质下神经回路和/或脊髓参与了观察到的效应。识别体感刺激对疼痛的神经机制可能为结合不同的靶向治疗疼痛控制开辟新的可能性。
Transcutaneous electrical stimulation has been proven to modulate nervous system activity, leading to changes in pain perception, via the peripheral sensory system, in a bottom up approach. We tested whether different sensory behavioral tasks induce significant effects in pain processing and whether these changes correlate with cortical plasticity. This randomized parallel designed experiment included forty healthy right-handed males. Three different somatosensory tasks, including learning tasks with and without visual feedback and simple somatosensory input, were tested on pressure pain threshold and motor cortex excitability using transcranial magnetic stimulation (TMS). Sensory tasks induced hand-specific pain modulation effects. They increased pain thresholds of the left hand (which was the target to the sensory tasks) and decreased them in the right hand. TMS showed that somatosensory input decreased cortical excitability, as indexed by reduced MEP amplitudes and increased SICI. Although somatosensory tasks similarly altered pain thresholds and cortical excitability, there was no significant correlation between these variables and only the visual feedback task showed significant somatosensory learning. Lack of correlation between cortical excitability and pain thresholds and lack of differential effects across tasks, but significant changes in pain thresholds suggest that analgesic effects of somatosensory tasks are not primarily associated with motor cortical neural mechanisms, thus, suggesting that subcortical neural circuits and/or spinal cord are involved with the observed effects. Identifying the neural mechanisms of somatosensory stimulation on pain may open novel possibilities for combining different targeted therapies for pain control.
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DOI：
10.1016/j.clinph.2009.08.016
发表时间：
2009-12
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Rossi S;Hallett M;Rossini PM;Pascual-Leone A;Safety of TMS Consensus Group
通讯作者：
Safety of TMS Consensus Group
影响因子：
3
作者：
Lane, John W.;Fitzgerald, Paul J.;Yau, Jeffrey M.;Pembeci, Izzet;Hsiao, Steven S.
通讯作者：
Hsiao, Steven S.
影响因子：
4.8
作者：
Dionne, Jennifer K.;Meehan, Sean K.;Staines, W. Richard
通讯作者：
Staines, W. Richard
DOI：
10.1002/art.24120
发表时间：
2008-10-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Imamura, Marta;Imamura, Satiko Tomikawa;Camanho, Gilberto Luis
通讯作者：
Camanho, Gilberto Luis
影响因子：
2.5
作者：
DARIANSMITH, C;DARIANSMITH, I
通讯作者：
DARIANSMITH, I