Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N-Ts Bond in a Different Light
Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N-Ts Bond in a Different Light
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DOI：
10.1002/chem.202102748
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发表时间：
2021-09-30
影响因子：
4.3
通讯作者：
Perry, Gregory J. P.
中科院分区：
文献类型：
--
作者：
Ozaki, Tomoya;Yorimitsu, Hideki;Perry, Gregory J. P.
尽管在有价值的分子中普遍存在，但显然缺乏转化磺胺类药物的方法。在这里，我们介绍了易于获得的磺酰基吡咯作为磺胺官能化的合成关键。磺酰基吡咯单元的多功能性通过化学、电化学和光化学途径产生各种产物来展示。还提供了关于伯磺酰胺直接官能化的初步结果，这可能导致新的活化模式。
Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.