Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren's Syndrome.
Increased Interleukin-17F is Associated with Elevated Autoantibody Levels and More Clinically Relevant Than Interleukin-17A in Primary Sjögren's Syndrome.
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在原发性干燥综合征中，白细胞介素 17F 增加与自身抗体水平升高相关，并且比白细胞介素 17A 更具临床相关性
DOI：
10.1155/2017/4768408
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发表时间：
2017
影响因子：
4.1
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Gan Y;Zhao X;He J;Liu X;Li Y;Sun X;Li Z
Th 17相关的免疫应答在原发性干燥综合征（pSS）中是致病性的。然而，IL-17 F，IL-17家族细胞因子中的一个有效的炎症成员，在pSS中的作用尚未明确。我们招募了109名pSS患者和42名健康对照，并通过多重细胞因子测定法测定其血清IL-17 A和IL-17 F水平。通过标准实验室技术测量白色血细胞、红细胞、中性粒细胞、淋巴细胞、IgM、IgG、C3、C4、RF、ANA、抗SSA抗体和抗SSB抗体。EULAR Sjögren综合征疾病活动指数（ESSDAI）评分也进行了相应的评价。我们发现IL-17 F在pSS患者中显著升高。IL-17 F水平升高与IgG和IgM升高、ANA和抗SSA抗体滴度升高以及C3和C4降低相关。疾病活动度较高的患者也显示出较高的血清IL-17 F水平。然而，血清IL-17 A仅在病程较长的患者中升高，并且与pSS患者的临床和实验室特征几乎没有相关性。总之，IL-17 F与pSS中增加的自身抗体水平和疾病活动性相关，并且比IL-17 A更具临床相关性。
Th17 related immune response is pathogenic in primary Sjögren's syndrome (pSS). However, the role of IL-17F, one potent inflammatory member of IL-17 family cytokines in pSS, has not been specifically defined. We recruited one hundred and nine pSS patients and forty-two healthy controls and their serum levels of IL-17A and IL-17F were determined by multiplex cytokine assays. White blood cell, red blood cell, neutrophil, lymphocyte, IgM, IgG, C3, C4, RF, ANA, anti-SSA antibody, and anti-SSB antibody were measured by standard laboratory techniques. EULAR Sjögren's syndrome disease activity index (ESSDAI) score was also evaluated accordingly. We found that IL-17F was significantly increased in pSS patients. Elevated levels of IL-17F were associated with increased IgG and IgM, higher titers of ANA and anti-SSA antibodies, and reduction of C3 and C4. Patients with higher disease activity also showed higher serum IL-17F levels. However, serum IL-17A was only increased in patients with longer disease duration and showed few correlation with clinical and laboratory features in pSS patients. In conclusion, IL-17F was correlated with increased autoantibody levels and disease activity in pSS and is more clinically relevant than IL-17A.