INITIATION OF HYPERTENSION INUTERO AND ITS AMPLIFICATION THROUGHOUT LIFE
INITIATION OF HYPERTENSION INUTERO AND ITS AMPLIFICATION THROUGHOUT LIFE
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DOI：
10.1136/bmj.306.6869.24
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发表时间：
1993-01-02
影响因子：
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通讯作者：
FALL, CHD
中科院分区：
文献类型：
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作者：
LAW, CM;DESWIET, M;FALL, CHD
确定高血压和低出生体重之间的关系是在子宫内还是在婴儿期开始的，以及它是否随年龄而变化。设计-儿童的纵向研究和成人的三个随访研究。设置-范堡罗，普雷斯顿，和赫特福德郡，英格兰，和英国的国家样本。受试者-1895名0-10岁的儿童，3240名36岁的男性和女性，459名46-54岁的男性和女性，1231名59-71岁的男性和女性。所有受试者的出生体重都记录下来。主要结果测量收缩压。结果在婴儿期以外的所有年龄段，出生体重较低的人收缩压较高。婴儿期收缩压与生长无关，与出生体重无关。随着年龄的增加，收缩压与出生体重之间的关系变得更大，因此，在考虑当前体重后，出生体重每增加1公斤，64-71岁年龄段的收缩压就会下降5.2 mm Hg（95%置信区间1.8至8.6）。结论-原发性高血压始于胎儿期。从婴儿到老年，血压升高可能会被正反馈机制放大。
Objective-To determine whether the relation between high blood pressure and low birth weight is initiated in utero or during infancy, and whether it changes with age.Design-A longitudinal study of children and three follow up studies of adults.Setting-Farnborough, Preston, and Hertfordshire, England, and a national sample in Britain.Subjects-1895 children aged 0-10 years, 3240 men and women aged 36 years, 459 men and women aged 46-54 years, and 1231 men and women aged 59-71 years. The birth weight of all subjects had been recorded.Main outcome measure-Systolic blood pressure.Results-At all ages beyond infancy people who had lower birth weight had higher systolic blood pressure. Systolic blood pressure was not related to growth during infancy independently of birth weight. The relation between systolic pressure and birth weight became larger with increasing age so that, after current body mass was allowed for, systolic pressure at ages 64-71 years decreased by 5.2 mm Hg (95% confidence interval 1.8 to 8.6) for every kg increase in birth weight.Conclusions-Essential hypertension is initiated in fetal life. A raised blood pressure is then amplified from infancy to old age, perhaps by a positive feedback mechanism.