Increased risk of lung cancer mortality among residents near an asbestos product manufacturing plant.
Increased risk of lung cancer mortality among residents near an asbestos product manufacturing plant.
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发表时间：
2010
影响因子：
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通讯作者：
S. Kumagai;N. Kurumatani;T. Tsuda;T. Yorifuji;E. Suzuki
中科院分区：
文献类型：
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作者：
S. Kumagai;N. Kurumatani;T. Tsuda;T. Yorifuji;E. Suzuki
我们调查了居住在石棉制造工厂附近的石棉暴露者是否会增加肺癌死亡率。我们研究了位于日本中部城市端岛的一个核电站附近的社区。从1943年到1991年，该厂使用石棉和温石棉型石棉纤维生产绝缘和包装材料。研究小组由577个家庭组成。我们通过问卷调查获得人口统计信息，并从死亡证明中确定已故家庭成员的潜在死亡原因。利用当地观测站每小时的气象数据，我们估计了工厂附近的相对石棉浓度，确定了四分位数边界，并指定了每个研究对象的环境暴露四分位数。最后，我们计算了标准化死亡率，以评估居住石棉与肺癌风险的关系。我们的研究结果有力地表明，与邻居接触石棉会增加男性和女性肺癌死亡率的风险。
We investigated whether individuals exposed to asbestos by living near an asbestos-manufacturing facility experienced increased lung cancer mortality. We studied a neighborhood around such a plant in the central Japanese city of Hashima. From 1943 to 1991 this plant produced insulation and packing material using amosite- and chrysotile-type asbestos fibers. The study group was comprised of 577 households. We obtained demographic information by a questionnaire and determined the underlying cause of death for deceased household members from death certificates. Using hourly meteorological data from local observatories, we estimated relative asbestos concentrations in the plant's vicinity, determined the quartile boundaries, and designated each study subject's quartile of ambient exposure. Finally, we calculated standardized mortality ratios to evaluate the association of residential asbestos with lung cancer risk. Our findings strongly suggest that neighborhood asbestos exposure can increase the risk of lung cancer mortality in men and probably in women.