Isolation of Enterococcus durans and Pseudomonas aeruginosa in a scid mouse colony
Isolation of Enterococcus durans and Pseudomonas aeruginosa in a scid mouse colony
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DOI：
10.1258/002367796780865754
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发表时间：
1996-04-01
影响因子：
2.4
通讯作者：
Albini, B
中科院分区：
文献类型：
--
作者：
Dietrich, HM;Khaschabi, D;Albini, B
在一群严重联合免疫缺陷（SCID）小鼠中，观察到明显改变的行为特征：弓背姿势、冷漠、迟钝、呼吸短促、毛发竖立、消瘦、绕其纵轴的盘旋运动和倾斜的头部姿势。这在妊娠和哺乳动物中最常见，在实验给药后的4只小鼠中也观察到。铜绿假单胞菌，血清型P1和肠球菌，血清型D分离自各种器官和中耳。尸检时，小鼠显示局灶性心包炎和肝包膜增厚的体征。肝脏组织学检查显示单核细胞轻度局灶性蓄积。此外，观察到具有该疾病体征的SCID小鼠不允许人外周血单核细胞植入。
In a colony of severe combined immunodeficiency (SCID) mice conspicuously altered behavioural characteristics were observed: hunched position, apathy, dullness, short breath, bristled fur, emaciation, circling movements around their longitudinal axis and oblique head posture. This was most common in pregnant and lactating animals and also observed in 4 mice after experimental treatment. Pseudomonas aeruginosa, serotype P1 and Enterococcus durans, serotype D were isolated from various organs and from the middle ear. On autopsy, the mice showed signs of focal pericarditis and thickened liver capsules. The histological examination of the liver revealed mild, focal accumulations of mononuclear cells. In addition, it was observed that SCID mice with signs of this disease did not allow human peripheral blood mononuclear cells to engraft.