Perfluoroalkyl substances and blood pressure in exposed young population in the Veneto Region, Italy
Perfluoroalkyl substances and blood pressure in exposed young population in the Veneto Region, Italy
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意大利威尼托地区接触全氟烷基物质的年轻人的血压
DOI：
10.1093/eurpub/ckaa166.107
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发表时间：
2020
影响因子：
4.4
通讯作者：
G. Pitter
中科院分区：
文献类型：
--
作者：
C. Canova;M Jare Zeddi;Giulia Barbieri;M. Gion;F. Daprà;F. Russo;T. Fletcher;G. Pitter
韦内托地区（意大利东北部）大面积地区的居民通过饮用水接触到全氟烷基物质（PFAS）。关于PFASs和血压（BP）水平之间关系的研究有限，结果不一致。利用区域健康监测项目的横断面数据，我们旨在量化PFAS血清浓度与血压和高血压患病率之间的关系。
该研究包括16，224名年龄在20-39岁之间的人。排除了孕妇（n = 327）、自我报告诊断或正在接受治疗的参与者（n = 296）或选定协变量信息缺失的参与者（n = 114），剩下15，487例受试者。高血压（HYP）定义为任何自我报告的诊断、使用降压药物或收缩压/舒张压（SBP）≥140，DBP ≥90 mmHg）升高。采用HPLC-MS法测定血清PFAS，用广义加性模型研究各PFAS（全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）、全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA））ln转换和十分位数转换后与SBP、DBP、HYP的关系，校正潜在混杂因素。
SBP和DBP均随转化血清PFASs浓度的增加而显著升高，且呈单调性。从PFOA的最低到最高十分位数，SBP和DBP的预测增加分别为1.62（95% CI = 0.69，2.55）和1.64 mmHg（95% CI = 0.96，2.31）。男性SBP和女性DBP的相关性更强。在男性中，每种In-PFAS增加一个单位与HYP几率增加呈正相关：PFOA OR = 1.07（1.01-1.14），PFOS OR = 1.18（1.05-1.32），PFHxS OR = 1.11（1.03-1.19），PFNA OR = 1.19（1.01-1.41）。
我们的研究结果表明，暴露于PFAS与血压升高有关，因此可能是心血管疾病发展的危险因素。
在大量高暴露的年轻成人人群中，血清PFAS与男性收缩压升高和女性舒张压升高相关。血清PFAS与男性高血压患病率升高相关。
Residents in a large area of the Veneto Region (North-Eastern Italy) were exposed to perfluoroalkyl substances (PFASs) via drinking water. Studies on the association between PFASs and blood pressure (BP) levels are limited and results are inconsistent. Using cross-sectional data from the Regional health surveillance program, we aimed to quantify the associations between PFAS serum concentrations and blood pressure and hypertension prevalence.
The study included 16,224 individuals aged 20-39 years. Pregnant women (n = 327), participants with self-reported diagnosis or under treatment (n = 296) or with missing information on the selected covariates (n = 114) were excluded, leaving 15,487 subjects. Hypertension (HYP) was defined as any self-reported diagnosis, use of antihypertensive drugs, or raised systolic/diastolic blood pressure (SBP)≥140, DBP ≥90 mmHg). Serum PFASs were measured by HPLC-MS. Generalized additive models were used to investigate the relation between each PFAS (perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)) ln transformed and by decile, and SBP, DBP, HYP, adjusted for potential confounders.
Both SBP and DBP increased significantly with an increase in the ln-transformed serum PFASs concentration in a monotonic way. The predicted increase in SBP and DBP were 1.62 (95% CI = 0.69, 2.55), 1.64 mmHg (95% CI = 0.96, 2.31) from lowest to highest decile of PFOA. The associations were stronger for SBP in men and DBP in women. One unit increase in each ln-PFAS was positively associated with an increased odds of HYP in men: PFOA OR = 1.07 (1.01-1.14), PFOS OR = 1.18 (1.05-1.32), PFHxS OR = 1.11 (1.03-1.19), PFNA OR = 1.19 (1.01-1.41).
Our findings suggest that exposure to PFAS is associated with increased blood pressure and thus may contribute as a risk factor for the development of cardiovascular diseases.
Serum PFASs were associated with raised systolic blood pressure in men and diastolic blood pressure in women in a large highly exposed young adult population. Serum PFASs were associated with raised prevalence of hypertension in men.