Endothelin and the glomerulus in chronic kidney disease.
Endothelin and the glomerulus in chronic kidney disease.
复制标题
内皮素和慢性肾脏疾病中的肾小球。
DOI：
10.1016/j.semnephrol.2015.02.005
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发表时间：
2015-03
影响因子：
3.3
通讯作者：
Sorokin A
中科院分区：
文献类型：
--
作者：
Barton M;Sorokin A
Endothelin-1 (ET-1) is a 21-amino acid peptide with mitogenic and powerful vasoconstricting properties. Under healthy conditions, ET-1 is constitutively expressed in all cells of the glomerulus and participates in homeostasis of glomerular structure and filtration function. Under disease conditions, increases in ET-1 are critically involved in initiating and maintaining glomerular inflammation, glomerular basement membrane hypertrophy, and injury of podocytes (visceral epithelial cells), thereby promoting proteinuria and glomerulosclerosis. Here, we review the role of ET-1 in the function of glomerular endothelial cells, visceral (podocytes) and parietal epithelial cells, mesangial cells, the glomerular basement membrane, stromal cells, inflammatory cells, and mesenchymal stem cells. We also discuss molecular mechanisms by which ET-1 – predominantly through activation of the ETA receptor - contributes to injury to glomerular cells and review preclinical and clinical evidence supporting its pathogenic role in glomerular injury in chronic renal disease. Finally, the therapeutic rationale for endothelin antagonists as a new class of antiproteinuric drugs is discussed.
